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1. (WO2007002258) BENZOCYCLOHEPTAPYRIDINES AS INHIBITORS OF THE RECEPTOR TYROSINE KINASE MET
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/002258    International Application No.:    PCT/US2006/024256
Publication Date: 04.01.2007 International Filing Date: 22.06.2006
IPC:
C07D 221/16 (2006.01), C07D 409/04 (2006.01), C07D 401/04 (2006.01), C07D 405/14 (2006.01), C07D 417/04 (2006.01), C07D 417/14 (2006.01), C07D 401/14 (2006.01), C07D 471/04 (2006.01), C07D 401/12 (2006.01), A61K 31/435 (2006.01), A61P 35/00 (2006.01)
Applicants: MERCK & CO., INC. [US/US]; 126 East Lincoln Avenue, Rahway, NJ 07065-0907 (US) (For All Designated States Except US).
DINSMORE, Christopher, J. [US/US]; (US) (For US Only).
JEWELL, James, P. [US/US]; (US) (For US Only).
KATZ, Jason, D. [US/US]; (US) (For US Only).
MACHACEK, Michelle, R. [US/US]; (US) (For US Only).
OTTE, Ryan, D. [US/US]; (US) (For US Only).
YOUNG, Jonathan, R. [US/US]; (US) (For US Only)
Inventors: DINSMORE, Christopher, J.; (US).
JEWELL, James, P.; (US).
KATZ, Jason, D.; (US).
MACHACEK, Michelle, R.; (US).
OTTE, Ryan, D.; (US).
YOUNG, Jonathan, R.; (US)
Common
Representative:
MERCK & CO., INC.; 126 East Lincoln Avenue, Rahway, NJ 07065-0907 (US)
Priority Data:
60/693,229 23.06.2005 US
60/729,061 21.10.2005 US
60/789,473 05.04.2006 US
Title (EN) BENZOCYCLOHEPTAPYRIDINES AS INHIBITORS OF THE RECEPTOR TYROSINE KINASE MET
(FR) INHIBITEURS DE TYROSINE KINASE
Abstract: front page image
(EN)The present invention relates to 5H-benzo[4,5]cyclohepta[1,2-b]pyridine derivatives, that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the receptor tyrosine kinase MET. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
(FR)La présente invention concerne des dérivés de 5H-benzo[4,5]cyclohepta[1,2-b]pyridine utiles pour traiter des maladies prolifératives cellulaires, pour traiter des troubles associés à l'activité de MET, et pour inhiber le récepteur tyrosine kinase MET. L'invention concerne également des compositions comprenant ces composés ainsi que leurs méthodes d'utilisation pour traiter le cancer chez des mammifères.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)