Search International and National Patent Collections
Some content of this application is unavailable at the moment.
If this situation persists, please contact us atFeedback&Contact
1. (WO2007002223) CD19 ANTIBODIES AND THEIR USES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/002223 International Application No.: PCT/US2006/024183
Publication Date: 04.01.2007 International Filing Date: 20.06.2006
IPC:
C07K 16/28 (2006.01) ,A61P 35/00 (2006.01) ,A61P 35/02 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
02
specific for leukemia
Applicants:
MEDAREX, INC. [US/US]; 707 State Road Princeton, NJ 08540, US (AllExceptUS)
RAO-NAIK, Chetana [US/US]; US (UsOnly)
KING, David, John [GB/US]; US (UsOnly)
LIU, Jie [CN/US]; US (UsOnly)
HUANG, Haichun [US/US]; US (UsOnly)
PASSMORE, David, B. [US/US]; US (UsOnly)
BELL, Alasdair, Fraser [GB/US]; US (UsOnly)
CARDARELLI, Josephine, M. [US/US]; US (UsOnly)
PAN, Chin [US/US]; US (UsOnly)
THI DO, To, Uyen [US/US]; US (UsOnly)
CHEN, Sharline [US/US]; US (UsOnly)
Inventors:
RAO-NAIK, Chetana; US
KING, David, John; US
LIU, Jie; US
HUANG, Haichun; US
PASSMORE, David, B.; US
BELL, Alasdair, Fraser; US
CARDARELLI, Josephine, M.; US
PAN, Chin; US
THI DO, To, Uyen; US
CHEN, Sharline; US
Agent:
BAKER BOTTS L.L.P.; 30 Rockefeller Plaza New York, NY 10112-4498, US
Priority Data:
60/692,53120.06.2005US
60/748,95608.12.2005US
60/804,08306.06.2006US
Title (EN) CD19 ANTIBODIES AND THEIR USES
(FR) ANTICORPS CD19 ET UTILISATIONS
Abstract:
(EN) The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to CD 19 with high affinity. Nucleic acid molecules encoding such CD 19 antibodies, expression vectors, host cells and methods for expressing the CD 19 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the CD 19 antibodies are also provided. Methods for detecting CD 19, as well as methods for treating various B cell malignancies, including non-Hodgkin's lymphoma, are disclosed.
(FR) La présente invention concerne des anticorps monoclonaux isolés, et plus particulièrement des anticorps monoclonaux humains se liant avec une affinité élevée spécifiquement au CD19. L'invention concerne également des molécules d'acide nucléique codant de tels anticorps CD19, des vecteurs d'expression, des cellules hôtes, et des procédés d'expression des anticorps CD19. L'invention concerne aussi des immunoconjugués, des molécules bi-spécifiques et des compositions pharmaceutiques comprenant les anticorps CD19. L'invention concerne enfin des procédés permettant de détecter le CD19, ainsi que des procédés destinés au traitement de diverses malignités des lymphocytes B, y-compris les lymphomes non Hodgkinniens.
front page image
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
HRP20080028ANO20080362NZ564593UAa200800643MXMX/a/2007/015944KR1020080032097
IL188088EP1899379BRPI0613279-0ZA2007/10916JP2008543339US20090142349
CN101233156CA2611814EA200800094AU2006262232IN4860/KOLNP/2007