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Machine translation
1. (WO2007002214) ACYL GUANIDINES AS BETA-SECRETASE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/002214    International Application No.:    PCT/US2006/024172
Publication Date: 04.01.2007 International Filing Date: 20.06.2006
IPC:
C07D 261/18 (2006.01), C07D 275/02 (2006.01), C07D 231/14 (2006.01), C07D 413/12 (2006.01), A61K 31/4155 (2006.01), A61P 25/28 (2006.01)
Applicants: BRISTOL-MYERS SQUIBB COMPANY [US/US]; Route 206 and Province Line Road, Princeton, New Jersey 08543-4000 (US) (For All Designated States Except US).
GERRITZ, Samuel [US/US]; (US) (For US Only).
ZHAI, Weixu [US/US]; (US) (For US Only).
SHI, Shuhao [US/US]; (US) (For US Only).
ZHU, Shirong [CN/US]; (US) (For US Only).
GOOD, Andrew C. [GB/US]; (US) (For US Only).
THOMPSON, Lorin, A., III [US/US]; (US) (For US Only)
Inventors: GERRITZ, Samuel; (US).
ZHAI, Weixu; (US).
SHI, Shuhao; (US).
ZHU, Shirong; (US).
GOOD, Andrew C.; (US).
THOMPSON, Lorin, A., III; (US)
Agent: ALGIERI, Aldo A., Ph. D.; Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, New Jersey 08543-4000 (US)
Priority Data:
60/692,600 21.06.2005 US
60/788,748 03.04.2006 US
Title (EN) ACYL GUANIDINES AS BETA-SECRETASE INHIBITORS
(FR) ACYLGUANIDINES EN TANT QU'INHIBITEUR DE BETA-SECRETASE
Abstract: front page image
(EN)There is provided a series of substituted acyl guanidines of Formula (I) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R1, R2. R3, R4 and R5 as defined herein, their pharmaceutical compositions and methods of use. These compounds inhibit the processing of amyloid precursor protein (APP) by Beta-secretase and, more specifically, inhibit the production of ABeta-peptide. The present disclosure is directed to compounds useful in the treatment of neurological disorders related to Beta-amyloid production, such as Alzheimer's disease and other conditions affected by anti-amyloid activity.
(FR)L'invention concerne une série de guanidines à substitution acyle représentées par la formule (I) ou un de leurs stéréoisomères ou un de leurs sels acceptables sur le plan pharmaceutique, dans laquelle R1, R2. R3, R4 et R5 correspondent à leur définition dans le descriptif, leurs compositions pharmaceutiques et méthodes d'utilisation. Ces composés inhibent l'effet exercé sur la protéine précurseur d'amyloïde (APP) par béta-sécrétase et, de façon plus spécifique, inhibent la production du Abéta-peptide. L'invention concerne des composés utiles pour le traitement de troubles neurologiques relatifs à la production des béta-amyloïdes, tels que la maladie d'Alzheimer ou d'autres états associés à l'activité anti-amyloïde.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)