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1. (WO2007002188) MPTENAKTS AS MODIFIERS OF THE PTEN/AKT PATHWAY AND METHODS OF USE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/002188    International Application No.:    PCT/US2006/024131
Publication Date: 04.01.2007 International Filing Date: 20.06.2006
IPC:
C12N 5/00 (2006.01), G01N 33/53 (2006.01)
Applicants: EXELIXIS, INC. [US/US]; 170 Harbor Way, P.O. Box 511, South San Francisco, CA 94083-0511 (US) (For All Designated States Except US).
BRACE, Arthur [US/US]; (US) (For US Only).
BJERKE, Lynn, Margaret [US/GB]; (GB) (For US Only).
NIETO-BERGMAN, Susana [US/US]; (US) (For US Only).
FRIEDMAN, Lori, S. [US/US]; (US) (For US Only).
WARD, Kevin [GB/US]; (US) (For US Only).
BLAKE, Robert, A. [GB/US]; (US) (For US Only)
Inventors: BRACE, Arthur; (US).
BJERKE, Lynn, Margaret; (GB).
NIETO-BERGMAN, Susana; (US).
FRIEDMAN, Lori, S.; (US).
WARD, Kevin; (US).
BLAKE, Robert, A.; (US)
Agent: SEPERACK, Peter, K.; Exelixis, Inc., 170 Harbor Way, P.O. Box 511, South San Francisco, CA 94083-0511 (US)
Priority Data:
60/692,342 20.06.2005 US
Title (EN) MPTENAKTS AS MODIFIERS OF THE PTEN/AKT PATHWAY AND METHODS OF USE
(FR) GENES MPTENAKT EN TANT GENES MODIFICATEURS DE LA VOIE PTEN/AKT ET METHODES D'UTILISATION
Abstract: front page image
(EN)Human MPTENAKT genes are identified as modulators of the PTEN/AKT pathway, and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT, comprising screening for agents that modulate the activity of MPTENAKT are provided.
(FR)Selon l'invention, des gènes MPTENAKT humains sont identifiés en tant que modulateurs de la voie PTEN/AKT, et sont par conséquent des cibles thérapeutiques pour des troubles associés à une fonction PTEN/AKT déficiente. L'invention concerne des méthodes d'identification de modulateurs de PTEN/AKT, faisant appel au criblage d'agents qui modulent l'activité de MPTENAKT.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)