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1. (WO2007002178) METHODS, IMMUNOASSAYS AND DEVICES FOR DETECTION OF ANTI-LIPOIDAL ANTIBODIES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/002178    International Application No.:    PCT/US2006/024117
Publication Date: 04.01.2007 International Filing Date: 20.06.2006
IPC:
G01N 33/571 (2006.01), G01N 33/92 (2006.01)
Applicants: THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; CENTERS FOR DISEASE CONTROL AND PREVENTION, TECHNOLOGY TRANSFER OFFER, 4770 Buford Highway (k79), Atlanta, GA 30341 (US) (For All Designated States Except US).
CASTRO, Arnold, R. [US/US]; (US) (For US Only).
GOERGE, Robert, W. [US/US]; (US) (For US Only).
POPE, Victoria [US/US]; (US) (For US Only)
Inventors: CASTRO, Arnold, R.; (US).
GOERGE, Robert, W.; (US).
POPE, Victoria; (US)
Agent: GORDON, Debra, A.; KLARQUIST SPARKMAN, LLP, ONE WORLD TRADE CENTER, SUITE 1600, 121 SW Salmon Street, Portland, OR 97204 (US)
Priority Data:
60/693,120 21.06.2005 US
Title (EN) METHODS, IMMUNOASSAYS AND DEVICES FOR DETECTION OF ANTI-LIPOIDAL ANTIBODIES
(FR) PROCEDES, IMMUNODOSAGES ET DISPOSITIFS POUR LA DETECTION D'ANTICORPS ANTI-LIPOIDAUX
Abstract: front page image
(EN)Compositions, methods and devices for the detection of anti-lipoidal antibodies and the diagnosis of disease, for example, syphilis, are described. In particular, a method for immobilizing a lipoidal antigen, comprising cardiolipin, lecithin, and cholesterol, on a solid support (such as a nitrocellulose membrane) is described. The ability to immobilize a lipoidal antigen on a membrane satisfies a long-felt need for membrane-based assay for the detection of anti-lipoidal antibodies. Also described are immunoassay devices for concurrently performing treponemal and non-treponemal tests for syphilis.
(FR)Compositions, procédés et dispositifs pour la détection d'anticorps anti-lipoïdaux et le diagnostic de maladies, par exemple la syphilis, et en particulier procédé d'immobilisation d'antigène lipoïdal, comprenant de la cardiolipine, de la lécithine et du cholestérol, sur un support solide (du type membrane nitrocellulosique). La capacité à immobiliser un antigène lipoïdal sur une membrane répond au besoin, existant de longue date, en dosage à base de membrane pour la détection d'anticorps anti-lipoïdaux. Dispositifs d'immunodosage pour la conduite simultanée d'essais de type tréponémal et non tréponémal en liaison avec la syphilis.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)