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1. (WO2007002114) 1,2-DIHYDRO-SPIRO(3H-INDOLE-3-4’-PIPERIDINE) COMPOUNDS AS MODULATORS OF THE MAS RECEPTOR NOVEL
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/002114 International Application No.: PCT/US2006/024020
Publication Date: 04.01.2007 International Filing Date: 21.06.2006
IPC:
C07D 471/10 (2006.01) ,A61K 31/435 (2006.01) ,A61P 9/00 (2006.01) ,A61P 25/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
10
Spiro-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
Applicants:
ARENA PHARMACEUTICALS, INC. [US/US]; 6166 Nancy Ridge Drive San Diego, California 92121-3223, US (AllExceptUS)
TRAN, Thuy-Anh [US/US]; US (UsOnly)
HAN, Sangdon [KR/US]; US (UsOnly)
BOATMAN, Douglas, P. [US/US]; US (UsOnly)
Inventors:
TRAN, Thuy-Anh; US
HAN, Sangdon; US
BOATMAN, Douglas, P.; US
Agent:
CAROL, Francis, L. ; Bozicevic, Field & Francis LLP 1900 University Avenue, Suite 200 East Palo Alto, CA 94303, US
Priority Data:
60/692,71622.06.2005US
Title (EN) 1,2-DIHYDRO-SPIRO(3H-INDOLE-3-4’-PIPERIDINE) COMPOUNDS AS MODULATORS OF THE MAS RECEPTOR NOVEL
(FR) COMPOSES 1,2-DIHYDRO-SPIRO(3H-INDOLE-3-4'-PIPERIDINE) COMME MODULATEURS DU NOUVEAU RECEPTEUR MAS
Abstract:
(EN) The present invention relates to certain 1,2-dihydro-spiro[3H-indole-3,4'-piperidine] compounds of Formula (Ia): and pharmaceutically acceptable salts, solvates and hydrates thereof, wherein G, R1, R2, R3, R4, R5, and Ar are as disclosed herein ('Compound(s) of the Invention'), which are useful, for example, as cardio-protective and/or neuro-protective agents. The invention also provides pharmaceutical compositions comprising a Compound of the Invention and methods for treating, preventing and/or managing a vascular, cardiovascular or neurological disease or disorder, comprising administering to a patient in need thereof a Compound of the Invention.
(FR) L'invention concerne certains composés 1,2-dihydro-spiro[3H-indole-3,4'-pipéridine] de formule (Ia), -ainsi que des sels pharmaceutiquement acceptables, des solvates et des hydrates de ceux-ci-, dans laquelle G, R1, R2, R3, R4, R5, et Ar sont tels que décrits dans la description; ces composés étant utilisés, par exemple, comme agents cardioprotecteurs et/ou neuroprotecteurs. Par ailleurs, l'invention concerne des compositions pharmaceutiques qui contiennent un composé de l'invention ainsi que des méthodes de traitement, de prévention et/ou de gestion de maladies ou de troubles vasculaires, cardiovasculaires ou neurologiques, qui consistant à administrer à un patient un composé de l'invention.
front page image
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP1899339US20080200491