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1. (WO2007002080) EYA2S AS MODIFIERS OF THE PTEN/AKT PATHWAY AND METHODS OF USE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/002080 International Application No.: PCT/US2006/023970
Publication Date: 04.01.2007 International Filing Date: 20.06.2006
IPC:
A61K 39/395 (2006.01) ,C12Q 1/68 (2006.01) ,G01N 33/574 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
574
for cancer
Applicants:
EXELIXIS, INC. [US/US]; 170 Harbor Way, P.O. Box 511 South San Francisco, CA 94083-0511, US (AllExceptUS)
BRACE, Arthur [US/US]; US (UsOnly)
BJERKE, Lynn, Margaret [US/GB]; GB (UsOnly)
NIETO-BERGMAN, Susana [US/US]; US (UsOnly)
FRIEDMAN, Lori, S. [US/US]; US (UsOnly)
WARD, Kevin [GB/US]; US (UsOnly)
BLAKE, Robert, A. [GB/US]; US (UsOnly)
Inventors:
BRACE, Arthur; US
BJERKE, Lynn, Margaret; GB
NIETO-BERGMAN, Susana; US
FRIEDMAN, Lori, S.; US
WARD, Kevin; US
BLAKE, Robert, A.; US
Agent:
SEPERACK, Peter, K. ; EXELIXIS, INC. 170 Harbor Way, P.O. Box 511 South San Francisco, CA 94083-0511, US
Priority Data:
60/692,34220.06.2005US
Title (EN) EYA2S AS MODIFIERS OF THE PTEN/AKT PATHWAY AND METHODS OF USE
(FR) EYA2S UTILISES COMME MODIFICATEURS DE LA VOIE DE PTEN/AKT ET LEURS PROCEDES D'UTILISATION
Abstract:
(EN) Human EYA2 genes are identified as modulators of the PTEN/AKT pathway, and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT, comprising screening for agents that modulate the activity of EYA2 are provided.
(FR) Les gènes EYA2 humains sont identifiés comme modulateurs de la voie de PTEN/AKT et sont donc des cibles thérapeutiques des troubles liés à la fonction défecteuse de PTEN/AKT. L'invention concerne également des procédés d'identification des modulateurs de PTEN/AKT, comportant le criblage d'agents qui modulent l'activité de EYA2.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
US20110135629