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1. (WO2007002057) CARBON-LINKED SUBSTITUTED PIPERIDINES AND DERIVATIVES THEREOF USEFUL AS HISTAMINE H3 ANTAGONISTS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/002057 International Application No.: PCT/US2006/023937
Publication Date: 04.01.2007 International Filing Date: 19.06.2006
IPC:
C07D 401/12 (2006.01) ,C07D 401/14 (2006.01) ,C07D 405/14 (2006.01) ,C07D 413/14 (2006.01) ,A61P 3/04 (2006.01) ,A61P 29/00 (2006.01) ,A61P 37/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14
containing three or more hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
04
Anorexiants; Antiobesity agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
Applicants:
SCHERING CORPORATION [US/US]; 2000 Galloping Hill Road Kenilworth, New Jersey 07033-0530, US (AllExceptUS)
ASLANIAN, Robert, G. [US/US]; US (UsOnly)
BERLIN, Michael, Y. [RU/US]; US (UsOnly)
HUANG, Ying [US/US]; US (UsOnly)
MCCORMICK, Kevin, D. [US/US]; US (UsOnly)
MUTAHI, Mwangi, W. [US/KE]; KE (UsOnly)
SHIH, Neng-Yang [US/US]; US (UsOnly)
TING, Pauline, C. [US/US]; US (UsOnly)
TOM, Wing, C. [US/US]; US (UsOnly)
ZHENG, Junying [CN/US]; US (UsOnly)
Inventors:
ASLANIAN, Robert, G.; US
BERLIN, Michael, Y.; US
HUANG, Ying; US
MCCORMICK, Kevin, D.; US
MUTAHI, Mwangi, W.; KE
SHIH, Neng-Yang; US
TING, Pauline, C.; US
TOM, Wing, C.; US
ZHENG, Junying; US
Agent:
RUSSELL, Mark, W.; Schering-Plough Corporation 2000 Galloping Hill Road Patent Department K-6-1 1990 Kenilworth, NJ 07033-0530, US
Priority Data:
60/692,17520.06.2005US
Title (EN) CARBON-LINKED SUBSTITUTED PIPERIDINES AND DERIVATIVES THEREOF USEFUL AS HISTAMINE H3 ANTAGONISTS
(FR) PIPÉRIDINES SUBSTITUÉES LIÉES À UN ATOME DE CARBONE ET LEURS DÉRIVÉS UTILES EN TANT QU’ANTAGONISTES DE L'HISTAMINE H3
Abstract:
(EN) Disclosed are compounds of the formula (I); or a pharmaceutically acceptable salt thereof, wherein: M1 and M3 are CH or N; M2 is CH, CF or N; Y is -C(=O)-, -C(=S)-, -(CH2)q-, -C(=NOR7)- or -SO1-2-; Z is a bond or optionally substituted alkylene or alkenylene; R1 is H, alkyl, alkenyl, or optionally substituted cycloalkyl, aryl, heteroaryl, heterocycloalkyl or a group of the formula (II); where ring A is a monoheteroaryl ring; R2 is optionally substituted alkyl, alkenyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl; and the remaining variables are as defined in the specification; compositions and methods of treating allergy-induced airway responses, congestion, obesity, metabolic syndrome nonalcoholic fatty liver disease, hepatic steatosis, nonalcoholic steatohepatitis, cirrhosis, hepatacellular carcinoma or cognition deficit disorders using said compounds, alone or in combination with other agents.
(FR) La présente invention concerne des composés répondant à la formule (I) ; ou un sel pharmaceutiquement acceptable de ceux-ci, où : M1 et M3 représentent CH ou N ; M2 représente CH, CF ou N ; Y représente -C(=O)-, -C(=S)-, -(CH2)q-, -C(=NOR7)- ou -SO1-2- ; Z représente une liaison ou un groupe alkylène ou alcénylène éventuellement substitué ; R1 représente H, un groupe alkyle, alcényle, ou un groupe cycloalkyle, aryle, hétéroaryle, hétérocycloalkyle éventuellement substitué ou un groupe répondant à la formule (II) ; où le cycle A est un cycle monohétéroaryle ; R2 représente un groupe alkyle, alcényle, aryle, hétéroaryle, cycloalkyle ou hétérocycloalkyle éventuellement substitué ; et les variables restantes sont telles que définies dans le mémoire descriptif ; des compositions et des méthodes de traitement des réponses des voies respiratoires induites par une allergie, d’une congestion, de l'obésité, d’une maladie du foie non alcoolique de syndrome métabolique, de la stéatose hépatique, de la stéatohépatite non alcoolique, de la cirrhose, du carcinome hépatocellulaire ou des troubles dus au déficit de cognition utilisant lesdits composés, seuls ou en combinaison avec d'autres agents.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
MXMX/a/2007/016523EP1896453JP2008543940CN101203510CA2609957