Search International and National Patent Collections
Some content of this application is unavailable at the moment.
If this situation persists, please contact us atFeedback&Contact
1. (WO2007002018) CHIMERAC TBP-TOXIN PROTEINS AS MUCOSAL ADJUVANTS FOR VACCINATION AGAINST NEISSERIAE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/002018 International Application No.: PCT/US2006/023879
Publication Date: 04.01.2007 International Filing Date: 20.06.2006
IPC:
C07K 14/00 (2006.01) ,C12P 21/04 (2006.01) ,A61K 39/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21
Preparation of peptides or proteins
02
having a known sequence of two or more amino acids, e.g. glutathione
04
Cyclic or bridged peptides or polypeptides, e.g. bacitracin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
Applicants:
VIRGINIA COMMONWEALTH UNIVERSITY [US/US]; 800 E. Leigh Street, Suite 113 Richmond, VA 23219, US (AllExceptUS)
CORNELISSEN, Cynthia, Nau [US/US]; US (UsOnly)
PRICE, Gregory [--/--]; US (UsOnly)
RUSSELL, Michael [--/--]; ** (UsOnly)
CONNELL, Terry [--/--]; ** (UsOnly)
Inventors:
CORNELISSEN, Cynthia, Nau; US
PRICE, Gregory; US
RUSSELL, Michael; **
CONNELL, Terry; **
Agent:
WHITHAM, Michael, E. ; Whitham, Curtis, Christofferson & Cook, PC 11491 Sunset Hills Road, Suite 340 Reston, VA 20190, US
Priority Data:
60/693,49924.06.2005US
Title (EN) CHIMERAC TBP-TOXIN PROTEINS AS MUCOSAL ADJUVANTS FOR VACCINATION AGAINST NEISSERIAE
(FR) PROTEINES DE TBP-TOXINE CHIMERE SERVANT D'ADJUVANTS PAR VOIE MUQUEUSE POUR UNE VACCINATION CONTRE NEISSERIAE
Abstract:
(EN) Chimeric fusion proteins including Neisseria transferrin binding proteins (Tbps) from N gonorrhoeae or N meningitidis are provided The fusion proteins elicit an antibody response in the mucosa of the urogenital or oropharynx tract as well as in the serum The resultin serum antibodies are cross-bactericidal against heterologous bacterial strains The chimeric proteins also comprise a mucosal adjuvant such as a toxin subunit, e g the B subunit of cholera toxin or of Escherichia coli heat labile toxin Il. Methods of inhibiting the growth of Neisseria species on mucosal surfaces of a mammal by either administering transferrin binding protein chimeras, or antibodies directed to the fusion proteins, to a mammal are also provided
(FR) La présente invention concerne des protéines de fusion chimères comprenant des protéines de liaison à la transferrine de Neisseria (Tbp) à partir, par exemple, de N. gonorrhoeae et/ou N. meningitidis. Les protéines de fusion provoquent une réponse des anticorps dans les muqueuses du conduit urogénital et/ou de l'oropharynx, ainsi que dans le sérum. Les anticorps de sérum résultants présentent une activité bactéricide croisée contre des souches bactériennes hétérologues. Les protéines chimères comprennent également un adjuvant par voie muqueuse tel qu'une sous-unité de toxine, par exemple la sous-unité B de la toxine cholérique ou de la toxine thermolabile escherichia coli II. Cette invention concerne également des procédés pour inhiber la croissance des espèces Neisseria sur des surfaces de muqueuses d'un mammifère, qui consiste à administrer au mammifère soit lesdites protéines de fusion selon cette invention, soit des anticorps dirigés contre les protéines de fusion selon cette invention.
front page image
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)