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1. (WO2007001975) PIPERIDINE DERIVATIVES USEFUL AS HISTAMINE H3 ANTAGONISTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/001975    International Application No.:    PCT/US2006/023800
Publication Date: 04.01.2007 International Filing Date: 19.06.2006
IPC:
C07D 401/12 (2006.01), C07D 401/14 (2006.01), C07D 405/14 (2006.01), C07D 413/14 (2006.01), A61P 3/04 (2006.01), A61P 29/00 (2006.01), A61P 37/00 (2006.01), C07D 409/14 (2006.01), C07D 471/04 (2006.01)
Applicants: SCHERING CORPORATION [US/US]; 2000 Galloping Hill Road, Kenilworth, New Jersey 07033-0530 (US) (For All Designated States Except US).
ASLANIAN, Robert, G. [US/US]; (US) (For US Only).
BERLIN, Michael, Y. [RU/US]; (US) (For US Only).
BOYCE, Christopher, W. [US/US]; (US) (For US Only).
CHAO, Jianhua [CN/US]; (US) (For US Only).
DE LERA RUIZ, Manuel [ES/US]; (US) (For US Only).
MANGIARACINA, Pietro [US/US]; (US) (For US Only).
MCCORMICK, Kevin, D. [US/US]; (US) (For US Only).
MUTAHI, Mwangi, W. [US/KE]; (KE) (For US Only).
ROSENBLUM, Stuart, B. [US/US]; (US) (For US Only).
SHIH, Neng-Yang [US/US]; (US) (For US Only).
SOLOMON, Daniel, M. [US/US]; (US) (For US Only).
TOM, Wing, C. [US/US]; (US) (For US Only).
VACCARO, Henry, A. [US/US]; (US) (For US Only).
ZHENG, Junying [CN/US]; (US) (For US Only).
ZHU, Xiaohong [CN/US]; (US) (For US Only)
Inventors: ASLANIAN, Robert, G.; (US).
BERLIN, Michael, Y.; (US).
BOYCE, Christopher, W.; (US).
CHAO, Jianhua; (US).
DE LERA RUIZ, Manuel; (US).
MANGIARACINA, Pietro; (US).
MCCORMICK, Kevin, D.; (US).
MUTAHI, Mwangi, W.; (KE).
ROSENBLUM, Stuart, B.; (US).
SHIH, Neng-Yang; (US).
SOLOMON, Daniel, M.; (US).
TOM, Wing, C.; (US).
VACCARO, Henry, A.; (US).
ZHENG, Junying; (US).
ZHU, Xiaohong; (US)
Agent: RUSSELL, Mark, W.; Schering-Plough Corporation, 2000 Galloping Hill Road, Patent Department K-6-1 1990, Kenilworth, NJ 07033-0530 (US)
Priority Data:
60/692,110 20.06.2005 US
Title (EN) PIPERIDINE DERIVATIVES USEFUL AS HISTAMINE H3 ANTAGONISTS
(FR) DÉRIVÉS DE LA PIPÉRIDINE UTILES COMME ANTAGONISTES DU RÉCEPTEUR H3 DE L'HISTAMINE
Abstract: front page image
(EN)Disclosed are novel compounds of the formula (I) or a pharmaceutically acceptable salt thereof, wherein: M1 and M3 are CH or N; M2 is CH, CF or N; Y is -C(=O)-, -C(=S)-, -(CH2)q-, -C(=NOR7)- or -SO1-2-; Z is a bond or optionally substituted alkylene or alkenylene; R1 is H, or alkyl, cycloalkyl, aryl, heteroaryl, heterocycloalkyl, all optionally substituted, or a group of the formula (II) where ring A is a heteroaryl ring; R2 is optionally substituted alkyl, alkenyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl; R3 is H, -C(O)NH2, or alkyl, aryl, cycloalkyl, heterocycloalkyl or heteroaryl, all optionally substituted; and the remaining variables are as defined in the specification; compositions and methods of treating allergy-induced airway responses, congestion, obesity, metabolic syndrome, alcoholic fatty liver disease, hepatic steatosis, nonalcoholic steatohepatitis, cirrhosis, hepatacellular carcinoma and cognition deficit disorders using said compounds, alone or in combination with other agents.
(FR)L'invention concerne de nouveaux composés de formule (I) ou des sels acceptables du point de vue pharmaceutique de ceux-ci, dans laquelle formule : M1 et M3 sont CH ou N; M2 est CH, CF ou N; Y est -C(=O)-, -C(=S)-, -(CH2)q-, -C(=NOR7)- ou -SO1-2-; Z est une liaison ou un alkylène ou alcénylène facultativement substitué; R1 est H ou un alkyle, cycloalkyle, aryle, hétéroaryle, hétérocycloalkyle, tous facultativement substitués, ou un groupe de formule (II) où le cycle A est un cycle hétéroaryle; R2 est un alkyle, alcényle, aryle, hétéroaryle, cycloalkyle ou hétérocycloalkyle facultativement substitué; R3 est H, -C(O)NH2 ou un alkyle, aryle, cycloalkyle, hétérocycloalkyle ou hétéroaryle, tous facultativement substitués; et les variables restantes sont telles que définies dans la description; des compositions et procédés de traitement de réactions des voies respiratoires induites par des allergies, de la congestion, de l'obésité, d'un syndrome métabolique, de la stéatose hépatique alcoolique, de la stéatose hépatique, de la stéatose hépatique non alcoolique, de la cirrhose, du cancer primitif du foie et de troubles liés à une déficience de la cognition utilisant lesdits composés, seuls ou en association avec d'autres agents.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)