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1. (WO2007001841) TREATMENT OF SEXUAL DYSFUNCTION
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/001841 International Application No.: PCT/US2006/023068
Publication Date: 04.01.2007 International Filing Date: 13.06.2006
IPC:
A61P 15/10 (2006.01) ,A61K 31/165 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15
Drugs for genital or sexual disorders; Contraceptives
10
for impotence
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
16
Amides, e.g. hydroxamic acids
165
having aromatic rings, e.g. colchicine, atenolol, progabide
Applicants:
SK HOLDINGS CO., LTD. [KR/KR]; 99 Seorin-dong Jongro-gu Seoul 110-110, KR (AllExceptUS)
PALUMBO, Joseph [US/US]; US
SPORN, Johathan [US/US]; US
STECKLER, Thomas [DE/BE]; BE
CHOI, Yong [US/US]; US
LEE, James, S. [US/US]; US
Inventors:
PALUMBO, Joseph; US
SPORN, Johathan; US
STECKLER, Thomas; BE
CHOI, Yong; US
LEE, James, S.; US
Agent:
JOHNSON, Philip, S.; JOHNSON & JOHNSON One Johnson & Johnson Plaza New Brunswick, NJ 08901-7003, US
Priority Data:
60/692,80922.06.2005US
Title (EN) TREATMENT OF SEXUAL DYSFUNCTION
(FR) TRAITEMENT DE DYSFONCTIONNEMENT SEXUEL
Abstract:
(EN) This invention is directed to a method of treating sexual dysfunction in a subject, comprising the step of administering a therapeutically effective amount of a compound of Formula (I): or a pharmaceutically acceptable salt or ester thereof wherein Rx is a member selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, halogen selected from F, CI, Br and I, alkoxy containing 1 to 3 carbon atoms, nitro, hydroxy, trifluoromethyl, and thioalkoxy containing 1 to 3 carbon atoms; x is an integer of 1 to 3, with the proviso that R may be the same or different when x is 2 or 3; R1 and R2 can be the same or different from each other and are independently selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, aryl, arylalkyl, cycloalkyl of 3 to 7 carbon atoms; R1 and R2 can be joined to form a 5 to 7-membered heterocycle substituted with a member selected from the group consisting of hydrogen, alkyl, and aryl groups, wherein the cyclic compound can comprise 1 to 2 nitrogen atoms and O to 1 oxygen atom, wherein the nitrogen atoms are not directly connected with each other or with the oxygen atom.
(FR) Procédé de traitement de dysfonctionnement sexuel : administration de quantité thérapeutiquement efficace de composé de formule (I), y compris un sel ou ester correspondant pharmaceutiquement acceptable, sachant que Rx peut être hydrogène, alkyle inférieur avec 1 à 8 atomes de carbone, halogène comme F, CI, Br et I, alcoxy avec 1 à 3 atomes de carbone, nitro, hydroxy, trifluorométhyle, et thioalcoxy avec 1 à 3 atomes de carbone; x est un entier compris entre 1 et 3, à condition que R puisse être identique ou différent lorsque x vaut 2 ou 3; R1 et R2 peuvent être identiques ou différents et sont indépendamment hydrogène, alkyle inférieur avec 1 à 8 atomes de carbone, aryle, arylalkyle, cycloalkyle avec 3 à 7 atomes de carbone; R1 et R2 peuvent être assemblés pour former un hétérocycle avec 5 à 7 éléments, substitué avec un élément pouvant être hydrogène, alkyle, et groupes aryle, sachant que le composé cyclique peut comporter 1 ou 2 atomes d'azote et 0 ou 1 atome d'oxygène ; les atomes d'azote ne sont pas directement liés entre eux ou avec l'atome d'oxygène.
front page image
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
KR1020080028445EP1893291JP2008546778US20090221553CA2612672MYPI 20062920
TH85417