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1. (WO2007001487) MODULATION OF NEGATIVE IMMUNE REGULATORS AND APPLICATIONS FOR IMMUNOTHERAPY
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/001487 International Application No.: PCT/US2006/001751
Publication Date: 04.01.2007 International Filing Date: 19.01.2006
IPC:
C07H 21/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
04
with deoxyribosyl as saccharide radical
Applicants:
BAYLOR COLLEGE OF MEDICINE [US/US]; One Baylor Plaza, Bcm 210-600D Houston, TX 77030, US (AllExceptUS)
CHEN, Si-Yi [US/US]; US (UsOnly)
EVEL-KABLER, Kevin, C. [US/US]; US (UsOnly)
SONG, Xiaotong [US/US]; US (UsOnly)
HUANG, Xue, F. [US/US]; US (UsOnly)
SHARABI, Andrew [US/US]; US (UsOnly)
Inventors:
CHEN, Si-Yi; US
EVEL-KABLER, Kevin, C.; US
SONG, Xiaotong; US
HUANG, Xue, F.; US
SHARABI, Andrew; US
Agent:
DOYLE, Kathryn; Drinker Biddle & Reath LLP One Logan Square, 18th And Cherry Streets Philadelphia, PA 19103, US
Priority Data:
PCT/US05/2239623.06.2005US
Title (EN) MODULATION OF NEGATIVE IMMUNE REGULATORS AND APPLICATIONS FOR IMMUNOTHERAPY
(FR) MODULATION DE REGULATEURS IMMUNES NEGATIFS ET APPLICATIONS POUR L'IMMUNOTHERAPIE
Abstract:
(EN) The invention includes compositions and methods for enhancing immunopotency of an immune cell by way of inhibiting a negative immune regulator in the cell. The present invention provides vaccines and therapies in which antigen presentation is enhanced through inhibition of negative immune regulators. The present invention also provides a mechanism to break self tolerance in tumor vaccination methods that rely on presentation of self tumor antigens.
(FR) Compositions et procédés permettant d'augmenter l'immuno-activité d'une cellule immune par inhibition de régulateur immune négatif dans la cellule. Vaccins et thérapies dans lesquels la présentation d'antigène est augmentée par inhibition de régulateurs immunes négatifs. Enfin, mécanisme éliminant la tolérance au soi dans les procédés de vaccination antitumeur qui reposent sur la présentation d'autoantigènes spécifiques à la tumeur.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
KR1020080052549EP1917038JP2008546775CA2613166CN101501055AU2006262917
IN9908/DELNP/2007