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1. (WO2007001451) STABILIZED HME COMPOSITION WITH SMALL DRUG PARTICLES

Pub. No.:    WO/2007/001451    International Application No.:    PCT/US2005/040535
Publication Date: Jan 4, 2007 International Filing Date: Nov 9, 2005
IPC: A61F 2/06
Applicants: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
MILLER, Dave, A.
MCCONVILLE, Jason, T.
MCGINITY, James, W.
WILLIAM, Robert, O., III
Inventors: MILLER, Dave, A.
MCCONVILLE, Jason, T.
MCGINITY, James, W.
WILLIAM, Robert, O., III
Title: STABILIZED HME COMPOSITION WITH SMALL DRUG PARTICLES
Abstract:
A hot-melt extruded composition having finely divided drug-containing particles dispersed within a carrier is provided. The carrier melts during extrusion but does not dissolve the drug. As a result a majority of the particles are noπaggregated during extrusion into crystalline or amorphous particles. Various excipients can be included in the carrier system to stabilize the particle size. A hydrophilic polymer can also be Included in the composition. A process for preparing the extrudate Is conducted at a temperature at or above the melting point of the matrix and below the point of solubilization of the drug-containing particles and below the rβcrystallization point of the amorphous fine-drug particles.