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1. (WO2007001448) COATED CONTROLLED RELEASE POLYMER PARTICLES AS EFFICIENT ORAL DELIVERY VEHICLES FOR BIOPHARMACEUTICALS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/001448 International Application No.: PCT/US2005/040100
Publication Date: 04.01.2007 International Filing Date: 04.11.2005
IPC:
A61K 9/14 (2006.01) ,A61K 9/16 (2006.01) ,A61K 31/70 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
14
Particulate form, e.g. powders
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
14
Particulate form, e.g. powders
16
Agglomerates; Granulates; Microbeadlets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
Applicants:
MASSACHUSETTS INSTITUTE OF TECHNOLOGY [US/US]; Five Cambridge Center Cambridge, MA 02142-1493, US (AllExceptUS)
JON, Sangyong [KR/US]; KR (UsOnly)
FAROKHAZD, Omid, C. [US/US]; US (UsOnly)
LANGER, Robert, S. [US/US]; US (UsOnly)
CHENG, Jianjun; US (UsOnly)
Inventors:
JON, Sangyong; KR
FAROKHAZD, Omid, C.; US
LANGER, Robert, S.; US
CHENG, Jianjun; US
Agent:
ROSEN, Valarie, B.; Choate Hall & Stewart LLP Two International Place Boston, MA 02110, US
Priority Data:
60/625,00104.11.2004US
Title (EN) COATED CONTROLLED RELEASE POLYMER PARTICLES AS EFFICIENT ORAL DELIVERY VEHICLES FOR BIOPHARMACEUTICALS
(FR) PARTICULES POLYMERES REVETUES A DIFFUSION REGULEE COMME VECTEURS EFFICACES D'ADMINISTRATION PAR VOIE ORALE DE PRODUITS BIOPHARMACEUTIQUES
Abstract:
(EN) A composition for delivering an active agent to a patient. The composition includes a polymer core encapsulating the active agent and a mucoadhesive coating disposed about the core. The polymer may include covalently linked poly(ethylene glycol) chains, and the mucoadhesive coating may be selected to facilitate transfer of the particle through the intestinal mucosa. A molecular weight and cross-link density of the polymer may be selected such that the polymer core will decompose in a predetermined time interval. The fraction of the dose of the drug entering the system at circulation during the predetermined time interval may be between about 0.25% and about 25%. The composition may be formulated as a plurality of nanoparticles or microparticles that are combined with a pharmaceutically acceptable carrier to produce an edible or inhalable drug product.
(FR) L'invention concerne une composition permettant d'administrer à un patient un principe actif, qui comporte un noyau polymère renfermant ledit principe actif, ledit noyau étant enrobé dans une enveloppe mucoadhésive. Le polymère peut comporter des chaînes poly(éthylène glycol) liées de manière covalente, et l'enveloppe mucoadhésive peut être choisie afin de faciliter le transport des particules à travers la muqueuse intestinale. On peut choisir un poids moléculaire et une densité de réticulation du polymère de façon que le noyau polymère se décompose dans un intervalle temporel prédéterminé. La fraction de la dose du médicament pénétrant dans le système pour la circulation durant l'intervalle temporel prédéterminé peut être comprise entre environ 0,25 % et environ 25 %. La composition peut être formulée comme une pluralité de nanoparticules ou microparticules qui sont combinées avec un support pharmaceutiquement acceptable pour produire un médicament comestible ou inhalable.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
US20080268063