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1. (WO2007001332) ANTI-PATHOGEN IMMUNOADHESINS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/001332 International Application No.: PCT/US2005/027944
Publication Date: 04.01.2007 International Filing Date: 04.08.2005
IPC:
A61K 39/385 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
385
Haptens or antigens, bound to carriers
Applicants:
UNIVERSITY OF MASSACHUSETTS [US/US]; 225 Franklin Street, 12th Floor Boston, MA 02110, US (AllExceptUS)
VISINTIN, Alberto [IT/US]; US (UsOnly)
GOLDENBOCK, Douglas T. [US/US]; US (UsOnly)
Inventors:
VISINTIN, Alberto; US
GOLDENBOCK, Douglas T.; US
Agent:
FASSE, J. Peter; FISH & RICHARDSON P.C. 225 Franklin Street Boston, MA 02110-2804, US
Priority Data:
60/598,77404.08.2004US
60/668,70306.04.2005US
Title (EN) ANTI-PATHOGEN IMMUNOADHESINS
(FR) IMMUNOADHESINES ANTI-PATHOGENE
Abstract:
(EN) Chimeric molecules that include a pathogen recognition module derived from a pathogen binding domain of a pathogen recognition protein, e.g., a toll-like receptor (TLR), CD14, BPI, MD-2, scavenger receptors (SRs), surfactant proteins (SP), C-reactive protein (CRP), Mannan-binding lectin (MBL), or complement C1q globular binding domain, an optional linker, and an Fc portion of an antibody are described and are useful for, e.g., drug discovery and treatment of conditions related to TLR signaling.
(FR) Cette invention concerne des molécules chimériques comprenant un module de reconnaissance d'un pathogène obtenu à partir d'un domaine de liaison à un pathogène d'une protéine de reconnaissance d'un pathogène, par exemple, un récepteur de type Toll (TLR), CD14, BPI, MD-2, des récepteurs détritivores (SR), des protéines tensioactives (SP), des protéines C-réactives (CRP), la lectine de liaison à Mannan (MBL), ou un domaine de liaison globulaire C1q complémentaire, un agent de liaison facultatif, et une portion Fc d'un anticorps, qui sont utiles, par exemple, pour la recherche de médicaments et pour le traitement d'affections associées à la signalisation du TLR.
front page image
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
US20090208501