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1. (WO2007001259) METHODS AND MATERIALS FOR IDENTIFYING POLYMORPHIC VARIANTS, DIAGNOSING SUSCEPTIBILITIES, AND TREATING DISEASE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/001259 International Application No.: PCT/US2005/021288
Publication Date: 04.01.2007 International Filing Date: 16.06.2005
IPC:
C12Q 1/68 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; Office of Technology Transfer 6011 Executive Boulevard Suite 325 Rockville, Maryland 20852, US (AllExceptUS)
THE PROVOST FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN [IE/IE]; College Green Dublin 2 Dublin, IE (AllExceptUS)
THE HEALTH RESEARCH BOARD [IE/IE]; 73 Lower Baggot St Dublin 2 Dublin, IE (AllExceptUS)
BRODY, Lawrence C.; null (UsOnly)
PARLE-MCDERMOTT, Anne; null (UsOnly)
SCOTT, John; null (UsOnly)
KIRKE, Peader; null (UsOnly)
MILLS, James; null (UsOnly)
PANGILINAN, Faith; null (UsOnly)
MOLLOY, Anne; null (UsOnly)
Inventors:
BRODY, Lawrence C.; null
PARLE-MCDERMOTT, Anne; null
SCOTT, John; null
KIRKE, Peader; null
MILLS, James; null
PANGILINAN, Faith; null
MOLLOY, Anne; null
Agent:
BUECHLE, Kurt T. ; Leydig, Voit & Mayer, LTD. Two Prudential Plaza, Suite 4900 180 N. Stetson Avenue Chicago, Illinois 60601, US
Priority Data:
Title (EN) METHODS AND MATERIALS FOR IDENTIFYING POLYMORPHIC VARIANTS, DIAGNOSING SUSCEPTIBILITIES, AND TREATING DISEASE
(FR) METHODES ET MATERIELS UTILISES POUR IDENTIFIER DES VARIANTES POLYMORPHES, DIAGNOSTIQUER DES PREDISPOSITIONS A DES PATHOLOGIES ET TRAITER DES MALADIES
Abstract:
(EN) The invention is directed to materials and methods associated with polymorphic variants in two enzymes involved in folate-dependent and one-carbon metabolic pathways: MTHFD1 (5,10- methylenetetrahydrofolate dehydrogenase, 5,10- methenyltetrahydrofolate cyclohydrolase, 10- formyltetrahydrofolate synthetase) and methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (MTHFD1L). Diagnostic and therapeutic methods are provided involving the correlation of polymorphic variants in MTHFD1, MTHFD1, and other genes with relative susceptibility for various pregnancy-related and other complications.
(FR) L'invention concerne les matériels et les méthodes associés aux variantes polymorphes de deux enzymes impliquées dans les voies métaboliques des monocarbones et dépendant des folates: MTHFD1 (5,10-méthylène-tétrahydrofolate déshydrogénase, 5,10-méthényltétrahydrofolate cyclohydrolase, 10- formyltétrahydrofolate synthétase) et méthylène tétrahydrofolate déshydrogénase (NADP+ dépendant) de type 1 (MTHFD1L). L'invention concerne des méthodes thérapeutiques et diagnostiques comprenant la mise en corrélation de variantes polymorphes dans MTHFD1, MTHFD1 et d'autres gènes avec un certain risque de présenter diverses complications liées à la grossesse, ainsi que d'autres complications.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)