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1. (WO2007001119) 2,2-DIMETHYL-3-ALKYLETHER-4-ALKOXY-6-ALKYL AMINO BENZOPYRANE AND THE DERIVATIVES THEREOF, AND PGE2 PRODUCTION INHIBITORS CONTAINING THE SAME AS AN EFFECTIVE INGREDIENT
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/001119    International Application No.:    PCT/KR2006/002023
Publication Date: 04.01.2007 International Filing Date: 26.05.2006
IPC:
C07D 311/22 (2006.01)
Applicants: AMOREPACIFIC CORPORATION [KR/KR]; 181, Hangang-ro 2ga, Yongsan-gu, Seoul 140-777 (KR) (For All Designated States Except US).
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY [KR/KR]; 100, Jang-dong, Yuseong-gu, Daejeon 305-600 (KR) (For All Designated States Except US).
GONG, Young Dae [KR/KR]; (KR) (For US Only).
LEE, Ill Young [KR/KR]; (KR) (For US Only).
LEE, Jong Cheol [KR/KR]; (KR) (For US Only).
CHO, Hee Young [KR/KR]; (KR) (For US Only).
HWANG, Jong Yeon [KR/KR]; (KR) (For US Only).
CHOI, Hyung Sub [KR/KR]; (KR) (For US Only).
JEON, Hyun Suk [KR/KR]; (KR) (For US Only).
YOO, Sung Eun [KR/KR]; (KR) (For US Only).
LEE, Chang Hoon [KR/KR]; (KR) (For US Only).
SUNG, Dae Seok [KR/KR]; (KR) (For US Only).
KIM, Kwang Mi [KR/KR]; (KR) (For US Only).
KIM, Dae Kwon [KR/KR]; (KR) (For US Only).
YANG, Hye Jin [KR/KR]; (KR) (For US Only).
KIM, Hyong June [KR/KR]; (KR) (For US Only).
PARK, Jong Hee [KR/KR]; (KR) (For US Only)
Inventors: GONG, Young Dae; (KR).
LEE, Ill Young; (KR).
LEE, Jong Cheol; (KR).
CHO, Hee Young; (KR).
HWANG, Jong Yeon; (KR).
CHOI, Hyung Sub; (KR).
JEON, Hyun Suk; (KR).
YOO, Sung Eun; (KR).
LEE, Chang Hoon; (KR).
SUNG, Dae Seok; (KR).
KIM, Kwang Mi; (KR).
KIM, Dae Kwon; (KR).
YANG, Hye Jin; (KR).
KIM, Hyong June; (KR).
PARK, Jong Hee; (KR)
Agent: YOON, Dong Yol; YOON & LEE International Patent, & Law, office, 9th Fl., Yosam Bldg. 648-23 Yoksam-dong Gangnam-gu (KR)
Priority Data:
10-2005-0045294 28.05.2005 KR
Title (EN) 2,2-DIMETHYL-3-ALKYLETHER-4-ALKOXY-6-ALKYL AMINO BENZOPYRANE AND THE DERIVATIVES THEREOF, AND PGE2 PRODUCTION INHIBITORS CONTAINING THE SAME AS AN EFFECTIVE INGREDIENT
(FR) 2,2-DIMÉTHYL-3-ALKYLÉTHER-4-ALCOXY-6-ALKYL AMINO BENZOPYRANE ET SES DÉRIVÉS ET INHIBITEURS DE LA PRODUCTION DE PGE2 QUI LES CONTIENNENT EN TANT QU'INGRÉDIENTS ACTIFS
Abstract: front page image
(EN)The present invention relates to 2,2-dimethyl-3-alkylether-4-alkoxy-6- alkyl amino benzopyran derivatives or the pharmaceutically available salts thereof; and a PGE2 production inhibitor containing the same, and a pharmaceutical composition for treating the inflammation related to PGE2 activity containing the same. The excellent PGE2 production inhibition effect of the 2-dimethyl-3- alkylether-4-alkoxy-6-alkyl amino benzopyran derivatives or the pharmaceutically available salts thereof is confirmed in the present invention by cell level and animal test, and the above compound is useful in developing therapeutics for inflammation disease induced by PGE2 activity.
(FR)La présente invention concerne des dérivés de 2,2-diméthyl-3-alkyléther-4-alcoxy-6-alkyl amino benzopyrane ou leurs sels disponibles sur le plan pharmaceutique, un inhibiteur de la production de PGE2 qui les contiennent et une composition pharmaceutique qui les contient et qui est destinée à traiter l'inflammation liée à l'activité PGE2. L'excellent effet d'inhibition de la production de PGE2 par les dérivés de 2,2-diméthyl-3-alkyléther-4-alcoxy-6-alkyl amino benzopyrane ou leurs sels disponibles sur le plan pharmaceutique est confirmé dans la présente invention au niveau cellulaire et par un test sur animal et le composé ci-dessus est utile pour la mise au point de traitements d'une maladie inflammatoire induite par l'activité PGE2.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: Korean (KO)