Search International and National Patent Collections
Some content of this application is unavailable at the moment.
If this situation persists, please contact us atFeedback&Contact
1. (WO2007001094) ARTIFICIAL LUNG SURFACTANT COMPOSITION
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/001094 International Application No.: PCT/JP2006/313434
Publication Date: 04.01.2007 International Filing Date: 28.06.2006
IPC:
C07K 14/785 (2006.01) ,A61K 38/00 (2006.01) ,A61P 11/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
785
Alveolar surfactant peptides; Pulmonary surfactant peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
Applicants:
李 相男 LEE, Sannamu [JP/JP]; JP
雪竹 浩 YUKITAKE, Ko [JP/JP]; JP
中村 幸弘 NAKAMURA, Yoshihiro [JP/JP]; JP (UsOnly)
Inventors:
李 相男 LEE, Sannamu; JP
雪竹 浩 YUKITAKE, Ko; JP
中村 幸弘 NAKAMURA, Yoshihiro; JP
Priority Data:
60/694,70129.06.2005US
Title (EN) ARTIFICIAL LUNG SURFACTANT COMPOSITION
(FR) COMPOSITION DE SURFACTANT DE POUMON ARTIFICIEL
(JA) 人工肺サーファクタント組成物
Abstract:
(EN) Disclosed is a peptide having a high surfactant activity and no hemolytic activity, in which D-amino acids comprise about 5 to 40% of the constituent amino acids. Also disclosed is a lung surfactant composition comprising the peptide and a natural lecithin (e.g., soybean lecithin). The composition is a promising composition for use as a lung surfactant pharmaceutical which contains no animal-derived substance, can be produced at low cost in a large quantity, and has a high surfactant activity.
(FR) L'invention concerne un peptide présentant une activité tensioactive importante et ne présentant pas d'activité hémolytique, les acides D-aminés représentant environ 5 à 40 % des acides aminés constitutifs dudit peptide. L'invention concerne également une composition de surfactant pulmonaire comprenant le peptide et une lécithine naturelle (par exemple, de la lécithine de soja). Cette composition est prometteuse pour une utilisation pharmaceutique en tant que surfactant pulmonaire ne contenant pas de substance animale. Elle peut être produite en grande quantité à faible coût, et présente une activité tensioactive importante.
(JA) この発明に係るペプチドは、高いサーファクタント活性を持ちかつ溶血活性を有していないペプチドであって、構成アミノ酸の約5%ないし40%がD-アミノ酸から構成されていることを特長とする。また、この発明に係る肺サーファクタント組成物は、かかるペプチドと、大豆レシチンなどの天然レシチンから構成されているところから、動物由来の物質を含まずかつ安価に資産可能な高いサーファクタント活性を有する肺サーファクタント医薬品として期待できる。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)
Also published as:
US20110195892