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1. (WO2007001006) AGENT FOR AMELIORATING HEAVY METAL-INDUCED DISORDERS, AND MEDICINAL COMPOSITION, FOOD AND COSMETIC CONTAINING THE SAME
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/001006 International Application No.: PCT/JP2006/312829
Publication Date: 04.01.2007 International Filing Date: 27.06.2006
IPC:
A61K 38/16 (2006.01) ,A23L 1/305 (2006.01) ,A61K 8/64 (2006.01) ,A61P 1/16 (2006.01) ,A61P 39/02 (2006.01) ,A61P 39/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
A HUMAN NECESSITIES
23
FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
L
FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D91; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
1
Foods or foodstuffs; Their preparation or treatment
29
Modifying nutritive qualities of foods; Dietetic products
30
containing additives
305
Amino acids, peptides or proteins 
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8
Cosmetics or similar toilet preparations
18
characterised by the composition
30
containing organic compounds
64
Proteins; Peptides; Derivatives or degradation products thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
16
for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
39
General protective or antinoxious agents
02
Antidotes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
39
General protective or antinoxious agents
04
Chelating agents
Applicants:
株式会社NRLファーマ NRL PHARMA, INC. [JP/JP]; 〒2130012 神奈川県川崎市高津区坂戸3-2-1 かながわサイエンスパーク Kanagawa Kanagawa Science Park, 3-2-1, Sakado, Takatsu-ku, Kawasaki-shi, Kanagawa 2130012, JP (AllExceptUS)
坪田 昭人 TSUBOTA, Akihito; null (UsOnly)
Inventors:
坪田 昭人 TSUBOTA, Akihito; null
Agent:
前 直美 MAE, Naomi; 〒1020074 東京都千代田区九段南3-7-12 九段津田ビル3階 サイリックス特許事務所 Tokyo Scilyx Patent Office, 3rd Floor, Kudan-Tsuda Bldg. 7-12, Kudanminami 3-chome, Chiyoda-ku, Tokyo 1020074, JP
Priority Data:
2005-18961929.06.2005JP
Title (EN) AGENT FOR AMELIORATING HEAVY METAL-INDUCED DISORDERS, AND MEDICINAL COMPOSITION, FOOD AND COSMETIC CONTAINING THE SAME
(FR) AGENT POUR AMÉLIORER LES TROUBLES INDUITS PAR LES MÉTAUX LOURDS, ET COMPOSITION MÉDICINALE, ALIMENT ET PRODUIT COSMÉTIQUE CONTENANT LADITE COMPOSITION
(JA) 重金属障害改善剤およびそれを含有する医薬組成物、食品、化粧料
Abstract:
(EN) It is intended to provide a drug for ameliorating symptoms or diseases caused by heavy metals (for example, Wilson’s disease, heavy metal toxication, aging, fulminant hepatitis and so on) which has a high safety without any fear of side effect, can eliminate heavy metals such as copper ion accumulated in excess in the living body to prevent or lessen the accumulation of the heavy metals in the living body, thereby eliminating or relieving the effects of the heavy metals; and compositions such as a medicinal composition, a food and a cosmetic containing the same. The drug and compositions as described above are characterized by containing lactoferrin and/or an active derivative of the same as the active ingredient.
(FR) L’invention concerne un médicament destiné à améliorer les symptômes ou les maladies provoqués par les métaux lourds (par exemple, la maladie de Wilson, l’intoxication par métaux lourds, le vieillissement, l’hépatite fulminante et ainsi de suite), de grande sûreté et sans risque d’effet annexe, susceptible d’éliminer les métaux lourds comme des ions de cuivre accumulés en excès dans le corps vivant pour empêcher ou amoindrir l’accumulation des métaux lourds dans le corps vivant, éliminant ou soulageant ainsi les effets des métaux lourds ; et des compositions de type composition médicinale, aliment et produit cosmétique contenant ledit médicament. Le médicament et les compositions selon la description ci-dessus sont caractérisés en ce qu’ils contiennent de la lactoferrine et/ou un dérivé actif de ladite lactoferrine comme ingrédient actif.
(JA)  本発明は、安全性が高くて副作用の心配がなく、生体に過剰蓄積した銅イオンなどの重金属イオンを排除することにより生体への重金属の蓄積を防止または低減し、その影響を排除または軽減することができる、ウイルソン病、重金属中毒、老化、劇症肝炎などをはじめとする重金属に起因する症状または疾患を改善するための薬剤およびこれを含有する医薬組成物、食品、化粧料などの組成物を提供する。  本発明の薬剤および組成物は、ラクトフェリンおよび/またはその活性誘導体を有効成分として含有することを特徴とする。
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)
Also published as:
EP1917972JPWO2007001006US20090082269CA2609954