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1. (WO2007000970) THERAPEUTIC AGENT FOR PAIN
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/000970 International Application No.: PCT/JP2006/312712
Publication Date: 04.01.2007 International Filing Date: 26.06.2006
IPC:
A61K 31/20 (2006.01) ,A61K 45/00 (2006.01) ,A61P 25/02 (2006.01) ,A61P 25/04 (2006.01) ,A61P 25/36 (2006.01) ,A61P 29/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
20
having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
02
for peripheral neuropathies
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
04
Centrally acting analgesics, e.g. opioids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
30
for treating abuse or dependence
36
Opioid-abuse
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
Applicants:
小野薬品工業株式会社 ONO PHARMACEUTICAL CO., LTD. [JP/JP]; 〒5418526 大阪府大阪市中央区道修町二丁目1番5号 Osaka 1-5, Doshomachi 2-chome, Chuo-ku, Osaka-shi, Osaka 5418526, JP (AllExceptUS)
前川 仁志 MAEGAWA, Hitoshi [JP/JP]; JP (UsOnly)
Inventors:
前川 仁志 MAEGAWA, Hitoshi; JP
Agent:
大家 邦久 OHIE, Kunihisa; 〒1030013 東京都中央区日本橋人形町二丁目14番6号 セルバ人形町6階 大家特許事務所 Tokyo OHIE Patent Office Selva-Ningyocho 6F 14-6, Nihonbashi-Ningyocho 2-chome Chuo-ku, Tokyo 1030013, JP
Priority Data:
2005-18591627.06.2005JP
Title (EN) THERAPEUTIC AGENT FOR PAIN
(FR) AGENT THÉRAPEUTIQUE CONTRE LA DOULEUR
(JA) 疼痛治療剤
Abstract:
(EN) Disclosed is an agent for prevention, treatment, inhibition of the progression of a condition of a pain and/or for control of an analgesic agent, the agent comprising (2R)-2-propyloctanoic acid or a salt or prodrug thereof, and the agent being intended to be administered in a single dose of 1 mg to 5000 mg (preferably 10 mg to 5000 mg). By the administration of (2R)-2-propyloctanoic acid or a salt or prodrug thereof in a single dose within the above-mentioned range, it becomes possible to significantly ameliorate a pain, particularly neurogenic pain (e.g., cancerous pain, postherpetic pain, diabetic pain, HIV-related neurogenic pain, calculus-induced pain, neuralgia, orofacial pain, a pain in a disease such as hyperalgesia) and to reduce adverse effects which may be produced as a result of the use of an analgesic agent and which are not desirable for a living body.
(FR) La présente invention décrit un agent destiné à la prévention, au traitement ou à l'inhibition de la progression d'un état pathologique ou d'une douleur et/ou au contrôle d'un agent analgésique, ledit agent comprenant de l'acide (2R)-2-propyloctanoïque ou un sel ou une prodrogue dudit composé, ledit agent étant destiné à être administré en une dose unique comprise entre 1 mg et 5 000 mg (préférentiellement entre 10 mg et 5 000 mg). Par le biais de l'administration de l'acide (2R)-2-propyloctanoïque ou d’un sel ou d’une prodrogue dudit composé en une dose unique comprise au sein de l'intervalle mentionné ci-avant, il devient possible de soulager de façon significative une douleur, en particulier une douleur neurogène (par exemple douleur liée au cancer, douleur postherpétique, douleur diabétique, douleur neurogène liée au VIH, douleur induite par un calcul, névralgie, douleur orofaciale, douleur induite par une maladie telle que l'hyperalgésie) et de réduire les effets secondaires contraires susceptibles de survenir lors de l'utilisation d'un agent analgésique et néfastes pour l'organisme.
(JA)  本発明は、1回あたりの投与量が1mg乃至5000mg(好ましくは10mg乃至5000mg)であることを特徴とする(2R)-2-プロピルオクタン酸、その塩、またはそのプロドラッグを含有してなる疼痛の予防、治療、症状進展抑制および/または鎮痛薬の調節剤に関する。(2R)-2-プロピルオクタン酸、その塩、またはそのプロドラッグを1回あたりに前記の範囲で投与することにより、疼痛、特に神経因性疼痛、例えば、癌性疼痛、帯状疱疹後疼痛、糖尿病性疼痛、HIV関連神経因性疼痛、結石誘発疼痛、神経痛、口腔顔面痛、または痛覚過敏等の疾患における疼痛を顕著に改善することができ、また、鎮痛薬の使用に関連する生体にとって好ましくない作用を軽減することができる。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)
Also published as:
EP1900363JPWO2007000970US20090030078EP2465499JP5050851