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1. (WO2007000939) THERAPEUTIC AGENT FOR LOCAL INFLAMMATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/000939    International Application No.:    PCT/JP2006/312570
Publication Date: 04.01.2007 International Filing Date: 23.06.2006
IPC:
A61K 31/07 (2006.01), A61K 9/48 (2006.01), A61K 31/203 (2006.01), A61K 47/02 (2006.01), A61K 47/04 (2006.01), A61P 19/02 (2006.01), A61P 29/00 (2006.01)
Applicants: ST. MARIANNA UNIVERSITY, SCHOOL OF MEDICINE [JP/JP]; 2-16-1, Sugao, Miyamae-ku, Kawasaki-shi, Kanagawa 2168511 (JP) (For All Designated States Except US).
IGARASHI, Rie [JP/JP]; (JP) (For US Only)
Inventors: IGARASHI, Rie; (JP)
Agent: SHIMIZU, Hatsushi; Kantetsu Tsukuba Bldg. 6F, 1-1-1, Oroshi-machi, Tsuchiura-shi, Ibaraki 3000847 (JP)
Priority Data:
2005-188605 28.06.2005 JP
Title (EN) THERAPEUTIC AGENT FOR LOCAL INFLAMMATION
(FR) AGENT THERAPEUTIQUE POUR L'INFLAMMATION LOCALE
(JA) 局所炎症治療用薬剤
Abstract: front page image
(EN)The agent comprises, as the main ingredient, a nanocapsule of an inorganic salt of a polyvalent metal which has a retinoid (e.g., retinoic acid) encapsulated therein. The agent can penetrate into a joint when applied onto the skin to thereby induce the production of hyaluronic acid in a synovial membrane or chondrocyte. When the nanocapsule is applied onto the skin for a certain period of time, the inflammatory cytokine level or MMP level in the blood can be reduced.
(FR)La présente invention concerne un agent comprenant, en tant que principal ingrédient, une nanocapsule d'un sel inorganique d'un métal polyvalent qui inclut un rétinoïde (ex. l'acide rétinoïque). Ledit agent est capable de pénétrer à l'intérieur d'une articulation lorsqu'il est appliqué sur la peau, afin d'induire ainsi la production d'acide hyaluronique à l'intérieur d'une membrane synoviale ou d'un chondrocyte. L'application de la nanocapsule sur la peau pendant une certaine durée permet de réduire le taux sanguin de cytokines inflammatoires ou le taux sanguin de MMP.
(JA) 本発明の薬剤は、レチノイン酸等のレチノイドを内包させた多価金属無機塩ナノカプセルを主成分とする。本薬剤は、皮膚に塗布することにより、関節内まで浸透し、滑膜や軟骨細胞からヒアルロン酸を産生させることができた。また、本発明のナノカプセルを一定期間皮膚に塗布することにより、血中の炎症性サイトカイン、MMPの値をも低下させた。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)