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1. (WO2007000676) GUANOSINE-RICH OLIGONUCLEOTIDES AS AGENTS FOR INDUCING CELL DEATH IN EUKARYOTIC CELLS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/000676 International Application No.: PCT/IB2006/002887
Publication Date: 04.01.2007 International Filing Date: 28.06.2006
IPC:
A61K 31/7088 (2006.01) ,A61P 35/00 (2006.01) ,C12N 15/11 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
Applicants:
JOHNSON & JOHNSON RESEARCH PTY. LTD. [AU/AU]; 1 Central Avenue Australian Technology Park Eveleigh, NSW 1430, AU (AllExceptUS)
RIVORY, Laurent, Pierre [AU/AU]; AU (UsOnly)
BIRKETT, Donald, John [AU/AU]; AU (UsOnly)
Inventors:
RIVORY, Laurent, Pierre; AU
BIRKETT, Donald, John; AU
Agent:
SPRUSON & FERGUSON; GPO 3898 Sydney, NSW 2001, AU
Priority Data:
60/694,74528.06.2005US
Title (EN) GUANOSINE-RICH OLIGONUCLEOTIDES AS AGENTS FOR INDUCING CELL DEATH IN EUKARYOTIC CELLS
(FR) OLIGONUCLÉOTIDES RICHES EN GUANOSINE EN TANT QU'AGENTS POUR L'INDUCTION DE MORT CELLULAIRE DANS DES CELLULES EUCARYOTES
Abstract:
(EN) The present invention relates to guanosine-rich oligonucleotides having the capacity to induce cell death, having characteristics of programmed cell death, in non-quiescent cells of higher eukaryotic organisms. The invention also relates to therapeutic methods involving the administration of these nucleic acid molecules to subjects suffering from, or being predisposed to, disorders involving abnormal cell proliferation and migration. The invention also concerns pharmaceutical compositions comprising the guanosine-rich nucleic acid molecules, in association with suitable carriers.
(FR) La présente invention a trait à des oligonucléotides riches en guanosine ayant la capacité d'induire la mort cellulaire, présentant des caractéristiques d'apoptose, dans des cellules non quiescentes d'organismes eucaryotes supérieurs. L'invention a également trait à des procédés thérapeutiques comprenant l'administration de ces molécules d'acide nucléique aux sujets atteints de troubles ou qui y sont prédisposés impliquant la prolifération et la migration cellulaire anormales. L'invention a trait en outre à des compositions pharmaceutiques comportant des molécules d'acide nucléique riches en guanosine, en combinaison avec des supports appropriés.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP1909803US20090312399AU2006263457