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1. (WO2007000675) RECOMBINANT TRIMERIC 4-1BBL
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/000675 International Application No.: PCT/IB2006/002484
Publication Date: 04.01.2007 International Filing Date: 20.06.2006
IPC:
C07K 14/52 (2006.01) ,C12N 5/00 (2006.01) ,C12N 15/62 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
52
Cytokines; Lymphokines; Interferons
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
62
DNA sequences coding for fusion proteins
Applicants:
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE [FR/FR]; 101, rue de Tolbiac F-75013 Paris, FR (AllExceptUS)
LANG, François [FR/FR]; FR (UsOnly)
RABU, Catherine [FR/FR]; FR (UsOnly)
Inventors:
LANG, François; FR
RABU, Catherine; FR
Agent:
VIALLE-PRESLES, Marie-José; CABINET ORES 36, Rue De St Pétersbourg F-75008 Paris, FR
Priority Data:
05291319.120.06.2005EP
Title (EN) RECOMBINANT TRIMERIC 4-1BBL
(FR) 4-1BBL TRIMERIQUES RECOMBINES
Abstract:
(EN) The invention relates to recombinant 4-1 BBL polypeptides comprising the whole extracellular domain of native 4-1 BBL, and a cross-linkable peptide domain. These recombinant polypeptides are able to associate into homotrimers. Said homotrimers have an inhibitory effect on the proliferation of T-lymphocytes. These homotrimers can be complexed or linked to a solid support through their cross-linkable domains. These cross-linked recombinant 4-1 BBL homotrimers have a costimulatory activity on T lymphocytes. The non-crosslinked form of trimeric recombinant 4-1 BBL can be used for inhibiting the proliferation of T-lymphocytes, while the crosslinked form can be used for activation and expansion of T lymphocytes.
(FR) L'invention concerne des polypeptides 4-1 BBL recombinés, comprenant le domaine extracellulaire complet de 4-1 BBL natifs, ainsi qu'un domaine peptidique pouvant être réticulé. Ces polypeptides recombinés sont capables de s'associer en homotrimères. Ces homotrimères présentent un effet inhibiteur sur la prolifération de lymphocytes T. Ces homotrimères peuvent être complexés ou liés à un support solide à travers leurs domaines pouvant être réticulés. Ces homotrimères 4-1 BBL recombinés réticulés possèdent une activité costimulatrice sur les lymphocytes T. La forme non réticulée de 4-1 BBL recombinés trimériques peut être utilisée pour inhiber la prolifération des lymphocytes T, alors que la forme réticulée peut être utilisée pour l'activation et l'expansion des lymphocytes T.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)