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1. WO2007000662 - NOVEL PROPOFOL COMPOSITION COMPRISING ASCORBIC ACID OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF

Publication Number WO/2007/000662
Publication Date 04.01.2007
International Application No. PCT/IB2006/001898
International Filing Date 01.02.2006
IPC
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
N
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
31
Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
08
Oxygen or sulfur directly attached to an aromatic ring system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
045
Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
05
Phenols
A01N 31/08 (2006.01)
A61K 31/05 (2006.01)
CPC
A61K 9/0019
A61K 9/1075
Y02A 50/473
Applicants
  • TARO PHARMACEUTICALS U.S.A., INC. [US/US]; 3 Skyline Drive Hawthome, NY 10532, US (AllExceptUS)
  • DIXIT, Suresh [US/US]; US
  • GOYAL, Sandhya [US/US]; US
  • OKECH, Frederick [US/US]; US
  • SHEK, Efraim [US/US]; US
Inventors
  • DIXIT, Suresh; US
  • GOYAL, Sandhya; US
  • OKECH, Frederick; US
  • SHEK, Efraim; US
Agents
  • GOLLIN, Michael; Venable L.L.P. P.O. Box 34385 Washington, DC 20043-9998, US
Priority Data
60/649,77703.02.2005US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL PROPOFOL COMPOSITION COMPRISING ASCORBIC ACID OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF
(FR) NOUVELLE COMPOSITION DE PROPOFOL COMPRENANT DE L'ACIDE ASCORBIQUE OU DES SELS PHARMACEUTIQUEMENT ACCEPTABLES DE CE DERNIER
Abstract
(EN)
Sterile pharmaceutical compositions for parenteral administration containing 2,6-diisopropylphenol (propofol) are described for use as anesthetics. The compositions comprise an oil-in- water emulsion of propofol additionally comprising an amount of ascorbic acid or its pharmaceutically acceptable salts thereof sufficient to prevent significant growth of microorganisms for at least 24 hours after adventitious contamination.
(FR)
L'invention concerne des compositions pharmaceutiques stériles destinées à l'administration parentérale qui contiennent du 2,6-diisopropylphénol (propofol) et qui sont utilisées en tant qu'anesthésiques. Les compositions comprennent une émulsion 'huile en eau' de propofol et comprennent en outre une certaine quantité d'acide ascorbique ou de ses sels pharmaceutiquement acceptables, suffisante pour empêcher la croissance significative de micro-organismes pendant au moins 24 heures après la contamination accidentelle.
Also published as
Latest bibliographic data on file with the International Bureau