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1. (WO2007000644) HOMOMORPHOLINE OXAZOLIDINONES AS ANTIBACTERIAL AGENTS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/000644 International Application No.: PCT/IB2006/001730
Publication Date: 04.01.2007 International Filing Date: 20.06.2006
IPC:
C07D 413/10 (2006.01) ,C07D 413/14 (2006.01) ,A61P 31/04 (2006.01) ,A61K 31/4178 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
containing two hetero rings
10
linked by a carbon chain containing aromatic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14
containing three or more hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04
Antibacterial agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4164
1,3-Diazoles
4178
not condensed and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
Applicants:
PHARMACIA & UPJOHN COMPANY LLC [US/US]; 7000 Portage Road Kalamazoo, Michigan 49001-0199, US (AllExceptUS)
JOSYULA, Vara Prasad Venkata Nagendra [US/US]; US (UsOnly)
BOYER, Frederick, Earl, Jr. [US/US]; US (UsOnly)
KIM, Ji-Young [US/US]; US (UsOnly)
Inventors:
JOSYULA, Vara Prasad Venkata Nagendra; US
BOYER, Frederick, Earl, Jr.; US
KIM, Ji-Young; US
Agent:
FULLER, Grover, F., Jr.; Pfizer Inc. 150 East 42nd Street New York, NY 10017-5612, US
Priority Data:
60/694,86229.06.2005US
Title (EN) HOMOMORPHOLINE OXAZOLIDINONES AS ANTIBACTERIAL AGENTS
(FR) OXAZOLIDINONES D'HOMOMORPHOLINE EN TANT QU'AGENTS ANTIBACTERIENS
Abstract:
(EN) The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein X is -C(=O)NHR4, or CH2-het; R1, R2, R3 are independently H or F; R4 is H, C1-6 alkyl, or OC1-6alkyl; het is a five (5)-membered heterocyclic ring having 1, 2 or 3 heteroatoms selected from the group consisting of non-peroxide oxygen, sulfur, and nitrogen within the ring. The compounds of the present are useful as antibacterial agents.
(FR) La présente invention a trait à un composé de formule (I) dans laquelle: X est -C(=O)NHR4, ou CH2-het; R1, R2, R3 sont indépendamment H ou F; R4 est H, alkyle en C1-C6, ou OC1-6alkyle; het est un noyau hétérocyclique à cinq chaînons ayant 1, 2, 3 hétéroatomes choisis parmi le groupe constitué d'oxygène non peroxyde, de soufre, et d'azote dans le noyau, ou un sel pharmaceutiquement acceptable de celui-ci. Les composés de la présente invention sont utiles en tant qu'agents antibactériens.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP1899331JP2008544979CA2610978DK1899331