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1. (WO2007000641) PROSTAGLANDIN DERIVATIVES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/000641 International Application No.: PCT/IB2006/001727
Publication Date: 04.01.2007 International Filing Date: 19.06.2006
IPC:
C07C 405/00 (2006.01) ,C07D 207/08 (2006.01) ,C07D 295/12 (2006.01) ,A61K 31/5575 (2006.01) ,A61P 27/06 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
405
Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
207
Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
04
having no double bonds between ring members or between ring members and non-ring members
08
with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
295
Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
04
with substituted hydrocarbon radicals attached to ring nitrogen atoms
12
substituted by singly or doubly bound nitrogen atoms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
557
Eicosanoids, e.g. leukotrienes
5575
having a cyclopentane ring, e.g. prostaglandin E2, prostaglandin F2-alpha
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27
Drugs for disorders of the senses
02
Ophthalmic agents
06
Antiglaucoma agents or miotics
Applicants:
PFIZER INC. [US/US]; 235 East 42nd Street New York, NY 10017, US (AllExceptUS)
NICOX S.A. [FR/FR]; Gaia II - 2455 Routes des Dolines, B.P. 313 F-06906 Sophia Antipolis Cedex, FR (AllExceptUS)
BENEDINI, Francesca [IT/IT]; IT (UsOnly)
CHIROLI, Valerio [IT/IT]; IT (UsOnly)
CHONG, Wesley, Kwan, Mung [US/US]; US (UsOnly)
KRAUSS, Achim [US/US]; US (UsOnly)
NIESMAN, Michael, Ross [US/US]; US (UsOnly)
ONGINI, Ennio [IT/IT]; IT (UsOnly)
Inventors:
BENEDINI, Francesca; IT
CHIROLI, Valerio; IT
CHONG, Wesley, Kwan, Mung; US
KRAUSS, Achim; US
NIESMAN, Michael, Ross; US
ONGINI, Ennio; IT
Agent:
FULLER, Grover, F., Jr.; c/o Lawrence, Jackie Pfizer Inc. MS8260-1615 Eastern Point Road CT, Groton, 06340, US
Priority Data:
60/696,38329.06.2005US
Title (EN) PROSTAGLANDIN DERIVATIVES
(FR) DERIVES DE PROSTAGLANDINE
Abstract:
(EN) Nitroderivatives of prostaglandin amides having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.
(FR) La présente invention a trait à des nitrodérivés d'amides de prostaglandine présentant une activité pharmacologique améliorée et une tolérabilité accrue. Ils peuvent être utilisés pour le traitement du glaucome et de l'hypertension oculaire.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
PE2007-0120EP1899295JP2009501150CA2613748MYPI 20063043