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1. (WO2007000582) HETEROCYCLIC NON-PEPTIDE GNRH ANTAGONISTS
Note: Text based on automatic Optical Character Recognition processes. Please use the PDF version for legal matters

CLAIMS
1. A compound of formula (I):



wherein
either B is absent and A and Z are the same or different and are each hydrogen, halogen, alkyl, hydroxy, alkoxy, -CN, -C(RC)2OH, -N(Rd)C(=X)Rc, -C(=X)N(Rc)(Rd), -S(O)m-Rc, -N(Rc)(Rd)S(O)2, -S(O)2N(Rc)(Rd), -N(Re)2) aryl optionally substituted with Ra or -O-aryl optionally substituted with Ra; or
B is present and is -(CH2)n-, -C(Rb)2- or -O-, or B taken together with A or Z can be -C=C(Rb)-, -C(Rb)=C-, -CH2-CH(Rb)- or -CH(Rb)-CH2-;
D is -O- or -S(O)n,-;
E is a bond or is -(CH2Jn-, -N(Rd)-, -(CH2)nN(Rd)- or -N(Rd)(CH2)n-;
F is -C(=X)-;
G is -(CHa)n-, -N(Rd)-, -(CH2)nN(Rd)- or -N(Rd)(CH2)n;
J is a bond or is -O-, -N(RC)C(=X)-, -C(=X)N(RC)-, -S(O)n,-, -N(Rc)S(O)m-, -S(O)mN(Rc)-, -N(Re)- or -N(R9)(Rh);
K is a bond or is alkylene optionally substituted with Rb; or K is cycloalkylene, cycloalkenylene, arylene, heterocycloalkylene, heterocycloalkylene or heteroarylene, any of which is optionally substituted with Ra;
L is hydrogen, halogen, -N(Rf)2, -CN, -SO2N(Ra)2, -SO2N=C[N(Ra)2],

-NHC(=O)NHORa, cycloalkyl, cycloalkenyl, aryl, heterocycloalkyl, heterocycloalkenyl or heteroaryl, any of which is optionally substituted with Ra, -C(=X)ORd, -OH, -ORC, -C(=X)N(Rb)(Rc), -S(O)mN(Rb)(Rc), -CN or a group of the formula

each Ra is the same or different and is hydrogen, halogen, alkyl, aryl, hydroxy, alkoxy, -alkoxy-(CH2)nC(=O)ORb, -O-aryl, -C(=X)RC, -NO2, -CN, -N(RC)C(=X)RC, -C(=X)N(RC)2, -S(O)2N(RC)2 or -N(Re)2;
each Rb is the same or different and is hydrogen or alkyl;
each Rc is the same or different and is alkyl, cycloalkyl, -alkyl-aryl, -alkyl-cycloalkyl or aryl optionally substituted with Ra;
each Rd is the same or different and is hydrogen or alkyl or aryl optionally with Ra;
each Re is the same or different and is hydrogen or alkyl; or Re is aryl or heteroaryl, either of which is optionally substituted with Ra;
each Rf is the same or different and is hydrogen or alkyl; or Rf-N-Rf taken together forms heterocycloalkyl, heterocycloalkenyl or heteroaryl, each of which is optionally substituted with Re;
each R9 is alkyl, cycloalkyl or alkyl-cycloalkyl, any of which is optionally substituted by an oxo and/or fluoro group;
each Rh is alkyl, cycloalkyl, or alkyl-cycloalkyl substituted with N(Rf)2; or R9 and Rh are taken together to form a heterocycloalkyl ring;
each X is the same or different and is oxygen or sulphur;
Ring 1 is a five- or six-membered heteroaryl ring containing at least 2 heteroatoms from O, N and/or S, which is optionally substituted with one or more Ra;
Ring 2 is arylene or heteroarylene, either of which is optionally substituted with one or more Ra;
each m is the same or different and is 0, 1 or 2; and
each n is the same or different and is 0, 1 , 2 or 3;
or a pharmaceutically acceptable salt thereof.
2. A compound according to claim 1 , wherein D is -O- or -S-.

3. A compound according to claim 1 or claim 2, wherein E is absent.
4. A compound according to any preceding claim, wherein F is -C(O)-.

5. A compound according to any preceding claim, wherein G is -N(Rd)-.

6. A compound according to claim 5, wherein Rd is hydrogen.
7. A compound according to any preceding claim, wherein J is -N(R8)- or -O-.
8. A compound according to any preceding claim, wherein K is ethylene or propylene.
9. A compound according to any preceding claim, wherein Ring 2 is phenylene, pyrimidylene or pyridinylene, any of which is optionally substituted.
10. A compound according to claim 10, wherein Ring 2 is substituted 1 , 2 or 3 times, the substituents being the same or different and selected from alkoxy, halogen and J-K-L.]
11. A compound according to any preceding claim, wherein either B is absent and A and Z are the same or different and are each hydrogen, halogen, alkyl, hydroxy, alkoxy, -CN, -N(Rd)C(=X)Rc, -C(=X)N(Rc)(Rd), -S(O)m-Rc, -N(Rc)(Rd)S(O)2, -S(O)2N(Ro)(Rd), -N(Re)2, aryl optionally substituted with Ra or -O-aryl optionally substituted with Ra; or
B is present and is -(CH2V, -C(Rb)2- or -O-, or B taken together with A or Z can be -C=C(Rb)-, -C(Rb)=C-, -CH2-CH(Rb)- or -CH(Rb)-CH2-;
J is a bond or is -O-, -N(RG)C(=X)-, -C(=X)N(RC)-, -S(O)m-, -N(Rc)S(O)m-, -S(O)mN(Rc)-, -N(Re)- or -N(Rg)(Rh);
L is hydrogen, halogen, -N(Rf)2, cycloalkyl, cycloalkenyl, aryl, heterocycloalkyl, heterocycloalkenyl or heteroaryl, any of which is optionally substituted with Ra, -C(=X)ORd, -OH, -ORC, -C(=X)N(Rb)(Rc), -S(O)mN(Rb)(Rc) or -CN; and
Ring 1 is a five- or six-membered heteroaryl ring containing at least 2 heteroatoms from O, N and/or S.
12. A compound according to any preceding claim, wherein Ring 1 is oxazole, thiazole or triazole.
13. A compound according to claim 11 , wherein Ring 1 is oxazole or thiazole.
14. A compound according to claim 1 , selected from: 2-(5-tert-butyl-2-methylphenoxy)-Λ/-(2-(2-(dimethylamino)ethylamino)-4,6-dimethoxypyrimidin-5-yl)oxazole-4-carboxamide
2-(5-tert-butyl-2-methylphenoxy)-Λ/-(2-(2-(dimethylamino)ethylamino)-4,6-dimethoxypyrimidin-5-yl)thiazole-4-carboxamide
2-(5-tert-butyl-2-methylphenoxy)-Λ/-(2-(dimethylamino)-4,6-dimethoxypyrimidin-5-yl)oxazole-4-carboxamide
2-(5-tert-butyl-2-methylphenoxy)-Λ/-(2-(dimethylamino)-4,6-dimethoxypyrimidin-5-yl)thiazole-4-carboxamide
2-(5-tert-butyl-2-methylphenoxy)-/V-(4,6-dimethoxy-2-(1 -methylazetidin-3-ylamino)pyrimidin-5-yl)oxazole-4-carboxamide
2-(5-tert-butyl-2-methylphenoxy)-/V-(4,6-dimethoxy-2-(1-methylazetidin-3-ylamino)pyrimidin-5-yl)thiazole-4-carboxamide
2-(3-teAt-butylphenoxy)-/V-(2-(2-(dimethylamino)ethylamino)-4,6-dimethoxypyrimidin-5-yl)oxazole-4-carboxamide
2-(3-tert-butylphenoxy)-/V-(2-(2-(dimethylamino)ethylamino)-4,6-dimethoxypyrimidin-5-yl)thiazole-4-carboxamide
2-(3-tørt-butylphenoxy)-Λ/-(2-(dimethylamino)-4J6-dimethoxypyrimidin-5-yl)oxazole-4-carboxamide
2-(3-tert-butylphenoxy)-/V-(2-(dimethylamino)-4,6-dimethoxypyrimidin-5-yl)thiazole-4-carboxamide
2-(3-tert-butylphenoxy)-/V-(4,6-dimethoxy-2-(1-methylazetidin-3-ylamino)pyrimidin-5-yl)oxazole-4-carboxamide
2-(3-tert-butylphenoxy)-/V-(4,6-dimethoxy-2-(1 -methylazetidin-3-ylamino)pyrimidin-5-yl)thiazole-4-carboxamide
2-(3-tert-butylphenoxy)-/V-(4,6-dimethoxy-2-(3-morpholinopropylamino)pyrimidin-5-yl)oxazole-4-carboxamide
2-(3-tert-butylphenoxy)-/V-(4,6-dimethoxy-2-(3-morpholinopropylamino)pyrimidin-5-yl)thiazole-4-carboxamide
2-(3,3-dimethyl-2,3-dihydro-1 H-inden-5-yloxy)-Λ/-(2-(2-(dimethylamino)ethylamino)-4,6-dimethoxypyrimidin-5-yl)oxazole-4-carboxamide
2-(3,3-dimethyl-2,3-dihydro-1 H-inden-5-yloxy)-N-(2-(2-(dimθthylamino)ethylamino)-4,6-dimethoxypyrimidin-5-yl)thiazolθ-4-carboxamide 2-(3,3-dimethyl-2)3-dihydro-1 H-inden-5-yloxy)-N-(2-(dimethylamino)-4,6-dimethoxypyrimidin-5-yl)oxazole-4-carboxamide
2-(3,3-dimethyl-2,3-dihydro-1 H-inden-5-yloxy)-A/-(2-(dimethylamino)-4,6-dimethoxypyrimidin-5-yl)thiazole-4-carboxamide
Λ/-(4,6-dimθthoxy-2-(1-methylazetidin-3-ylamino)pyrimidin-5-yl)-2-(3,3-dimethyl-2,3-dihydro-1 /-/-inden-5-yloxy)oxazole-4-carboxamide
Λ/-(4,6-dimethoxy-2-(1-methylazetidin-3-ylamino)pyrimidin-5-yl)-2-(3,3-dimethyl-2,3-dihydro-1 H-inden-5-yloxy)thiazole-4-carboxamide
Λ/-(2-(2-(dimethylamino)θthylamino)-4,6-dimethoxypyrimidin-5-yl)-2-(3,3,6-trimethyl-2,3-dihydro-1 /-/-inden-5-yloxy)oxazole-4-carboxamide
Λ/-(2-(2-(dimethylamino)θthylamino)-4,6-dimethoxypyrimidin-5-yl)-2-(3,3,6-trimethyl-2,3-dihydro-1 H-inden-5-yloxy)thiazolθ-4-carboxamide
Λ/-(2-(dimethylamino)-4,6-dimethoxypyrimidin-5-yl)-2-(3,3,6-trimethyl-2,3-dihydro-1 H-inden-5-yloxy)oxazole-4-carboxamide
N-(2-(dimethylamino)-4,6-dimethoxypyrimidin-5-yl)-2-(3,3,6-trimethyl- 2,3-dihydro-1 H-inden-5-yloxy)thiazole-4-carboxamide
Λ/-(4,6-dimethoxy-2-(1-methylazetidin-3-ylamino)pyrimidin-5-yI)-2-(3,3,6-trimethyl-2,3-dihydro-1 H-inden-5-yloxy)oxazole-4-carboxamide
Λ/-(4,6-dimethoxy-2-(1-methylazetidin-3-ylamino)pyrimidin-5-yl)-2-(3,3,6-trimethyl-2,3-dihydro-1 H-inden-5-yloxy)thiazole-4-carboxamide
2-(5-tert-butyl-2-methylphenoxy)-Λ/-(4,6-dimethoxy-2-(methylamino)pyrimidin-5-yl)oxazole-4-carboxamide
2-(5-tert-butyl-2-methylphenoxy)-Λ/-(2-(3-(dimethylamino)propylamino)-4,6-dimethoxypyrimidin-5-yl)oxazole-4-carboxamide
Λ/-(2-(2-aminoethylamino)-4,6-dimethoxypyrimidin-5-yl)-2-(5-tert-butyl- 2-methylphenoxy)oxazole-4-carboxamide
2-(5-tert-butyl-2-methylphenoxy)-Λ/-(4,6-dimethoxy-2-(2-(methylamino)ethylamino)pyrimidin-5-yl)oxazole-4-carboxamide
2-(5-tert-butyl-2-methylphenoxy)-Λ/-(2-(2-(ethyl(methyl)amino)ethylamino)-4,6-dimethoxypyrimidin-5-yl)oxazole-4-carboxamide
Λ/-(2-(2-(azetidin-1 -yl)θthylamino)-4,6-dimethoxypyrimidin-5-yl)-2-(5-tert-butyl-2-methylphenoxy)oxazole-4-carboxamide 2-(5-tert-butyl-2-methylphenoxy)-/V-(4,6-dimethoxy-2-(2-(pyrrolidin-1 -yl)ethylamino)pyrimiclin-5-yl)oxazole-4-carboxamicle
2-(5-tert-butyl-2-methylphθnoxy)-Λ/-(4,6-dimethoxy-2-(3-(pyrrolidin-1 -yl)propylamino)pyrimidin-5-yl)oxazole-4-carboxamide
2-(5-tert-butyl-2-methylphenoxy)-Λ/-(2-((2- (dimethylamino)ethyl)(methyl)amino)-4,6-dimethoxypyrimidin-5-yl)oxazole-4-carboxamide .
2-(5-tert-butyl-2-methylphenoxy)-/V-(2-((2- (trimethylammonium)ethyl)amino)-4,6-dimethoxypyrimidin-5-yl)oxazole-4-carboxamide iodide
2-(5-terf-butyl-2-methylphenoxy)-Λ/-(4,6-dimethoxy-2-(1 -methylpiperidin-4-ylamino)pyrimidin-5-yl)oxazole-4-carboxamide
2-(5-tørt-butyl-2-methylphenoxy)-Λ/-(4,6-dimethoxy-2-(piperidin-4-ylamino)pyrimidin-5-yl)oxazole-4-carboxamide
2-(5-tert-butyl-2-methylphenoxy)-/V-(4,6-dimethoxy-2-(1 -methylpiperidin-4-yloxy)pyrimidin-5-yl)oxazole-4-carboxamide
2-(5-tø/ϊ-butyl-2-methylphenoxy)-Λ/-(4,6-dimethoxy-2-(piperidin-4-yloxy)pyrimidin-5-yl)oxazole-4-carboxamide
Λ/-(2-(azetidin-3-ylamino)-4]6-dimethoxypyrimidin-5-yl)-2-(5-tert-butyl-2-methylphenoxy)oxazole-4-carboxamide
2-(5-tert-butyl-2-methylphenoxy)-/V-(4,6-dimethoxy-2-(1-methylazetidin-3-yloxy)pyrimidin-5-yl)oxazole-4-carboxamide
Λ/-(2-(azetidin-3-yloxy)-4,6-dimethoxypyrimidin-5-yl)-2-(5-tert-butyl-2-methylphenoxy)oxazole-4-carboxamide
Λ/-(2-(3-aminopyrrolidin-1-yl)-4,6-dimethoxypyrimidin-5-yl)-2-(5-tert-butyl-2-methylphenoxy)oxazole-4-carboxamide
2-(5-terf-butyl-2-methylphenoxy)-/V-(2-((1 -ethylpyrrolidin-2-yl)methylamino)-4,6-dimethoxypyrimidin-5-yl)oxazole-4-carboxamide
2-(5-tert-butyl-2-methylphenoxy)-Λ/-(2-((pyrrolidin-2-yl)methylamino)-4,6-dimethoxypyrimidin-5-yl)oxazole-4-carboxamide
2-(5-tert-butyl-2-methylphenoxy)-N-(2-(2-hydroxyethylamino)-4,6-dimethoxypyrimidin-5-yl)oxazole-4-carboxamide
2-(5-tert-butyl-2-methylphenoxy)-N-(2-(2-hydroxyethylamino)-4,6-dimethoxypyrimidin-5-yl)thiazole-4-carboxamide N-(2-(2-aminoethylamino)-4,6-dimethoxypyrimidin-5-yl)-2-(5-tert-butyl-2-methylphenoxy)thiazole-4-carboxamide
2-(5-tert-butyl-2-methylphenoxy)-N-(4,6-dimethoxy-2-(2-(methylamino)ethylamino)pyrimidin-5-yl)thiazole-4-carboxamide
2-(5-tert-butyl-2-methylphenoxy)-N-(2-(2-(ethylamino)ethylamino)-4,6-dimethoxypyrimidin-5-yl)oxazole-4-carboxamide
2-(5-tert-butyl-2-methylphenoxy)-N-(2-(2-(ethylamino)ethylamino)-4,6-dimethoxypyrimidin-5-yl)thiazolθ-4-carboxamide
2-(5-tert-butyl-2-methylphenoxy)-N-(2-(2-(isopropylamino)ethylamino)-4,6-dimethoxypyrimidin-5-yl)oxazole-4-carboxamide
2-(5-tert-butyl-2-methylphenoxy)-N-(2-(2-(isopropylamino)ethylamino)-4,6-dimethoxypyrimidin-5-yl)thiazole-4-carboxamide
2-(5-tert-butyl-2-methylphenoxy)-N-(2-(2-(tert-butylamino)ethylamino)-4,6-dimethoxypyrimidin-5-yl)oxazole-4-carboxamide
2-(5-tert-butyl-2-methylphenoxy)-N-(2-(2-(tert-butylamino)ethylamino)- 4,6-dimethoxypyrimidin-5-yl)thiazole-4-carboxamide
N-(2-(2-hydroxyethylamino)-4,6-dimethoxypyrimidin-5-yl)-2-(5-isopropyl-2-methylphenoxy)oxazole-4-carboxamide
N-(2-(2-hydroxyethylamino)-4,6-dimethoxypyrimidin-5-yl)-2-(5-isopropyl-2-methylphenoxy)thiazole-4-carboxamide
N-(2-(2-aminoethylamino)-4,6-dimethoxypyrimidin-5-yl)-2-(5-isopropyl-2-methylphenoxy)oxazole-4-carboxamide
N-(2-(2-aminoethylamino)-4,6-dimethoxypyrimidin-5-yl)-2-(5-isopropyl-2-methylphenoxy)thiazole-4-carboxamidθ
N-(416-dimethoxy-2-(2-(methylamino)ethylamino)pyrimidin-5-yi)-2-(5-isopropyl-2-methylphenoxy)oxazolθ-4-carboxamide
N-(4,6-dimethoxy-2-(2-(methylamino)ethylamino)pyrimidin-5-yl)-2-(5-isopropyl-2-methylphenoxy)thiazole-4-carboxamide
N-(4,6-dimethoxy-2-(2-(ethylamino)ethylamino)pyrimidin-5-yl)-2-(5-isopropyl-2-methylphenoxy)oxazole-4-carboxamide
N-(4,6-dimethoxy-2-(2-(ethylamino)ethylamino)pyrimidin-5-yl)-2-(5-isopropyl-2-methylphenoxy)thiazole-4-carboxamide
2-(5-isopropyl-2-methylphenoxy)-N-(2-(2-(isopropylamino)ethylamino)-4,6-dimethoxypyrimidin-5-yl)oxazole-4-carboxamide 2-(5-isopropyl-2-methylphenoxy)-N-(2-(2-(isopropylamino)ethylamino)-4,6-dimethoxypyrimidin-5-yl)thiazole-4-carboxamicle
N-(2-(2-(tert-butylamino)ethylamino)-4,6-dimethoxypyrimiciin-5-yl)-2-(5-isopropyl-2-methylphenoxy)oxazole-4-carboxamide
N-(2-(2-(tθrt-butylamino)ethylamino)-4,6-dimethoxypyrimidin-5-yl)-2-(5-isopropyl-2-methylphenoxy)thiazole-4-carboxamide
N-(2-(2-hydroxyethylamino)-4,6-dimethoxypyrimidin-5-yl)-2-(3,3,6-trimethyl-2,3-dihydro-1 H-inden-5-yloxy)oxazole-4-carboxamide
N-(2-(2-hydroxyethylamino)-4,6-dimethoxypyrimidin-5-yl)-2-(3,3,6-trimethyl-2,3-dihydro-1 H-inden-5-yloxy)thiazole-4-carboxamide
N-(2-(2-aminoethylamino)-4,6-dimethoxypyrimidin-5-yl)-2-(3,3,6-trimethyl-2,3-dihydro-1 H-inden-5-yloxy)oxazole-4-carboxamide
N-(2-(2-aminoethylamino)-4,6-dimethoxypyrimidin-5-yl)-2-(3,3,6-trimethyl-2,3-dihydro-1 H-inden-5-yloxy)thiazole-4-carboxamide
N-(4,6-dimethoxy-2-(2-(methylamino)ethylamino)pyrimidin-5-yl)-2- (3,3,6-trimethyl-2,3-dihydro-1 H-inden-5-yloxy)oxazole-4-carboxamide
N-(4,6-dimethoxy-2-(2-(methylamino)ethylamino)pyrimidin-5-yl)-2-(3,3,6-trimethyl-2,3-dihydro-1 H-inden-5-yloxy)thiazole-4-carboxamide
N-(2-(2-(ethylamino)ethylamino)-4,6-dimethoxypyrinnidin-5-yl)-2-(3,3,6-trimethyl-2,3-dihydro-1 H-inden-5-yloxy)oxazole-4-carboxamide
N-(2-(2-(θthylamino)ethylamino)-4,6-dimethoxypyrimidin-5-yl)-2-(3,3,6-trimethyl-2,3-dihydro-1H-inden-5-yloxy)thiazoie-4-carboxamide
N-(2-(2-(isopropylamino)ethylamino)-4,6-dimethoxypyrimidin-5-yl)-2-(3,3,6-trimethyl-2,3-dihydro-1 H-inden-5-yloxy)oxazole-4-carboxamide
N-(2-(2-(isopropylamino)ethylamino)-4,6-dimethoxypyrimidin-5-yl)-2- (3,3,6-trimethyl-2,3-dihydro-1 H-inden-5-yloxy)thiazole-4-carboxannide
N-(2-(2-(tert-butylamino)ethylamino)-4,6-dimethoxypyrimidin-5-yl)-2-(3,3,6-trimethyl-2,3-dihydro-1 H-inden-5-yloxy)oxazole-4-carboxamide
N-(2-(2-(tert-butylamino)ethylamino)-4,6-dimethoxypyrimidin-5-yl)-2-(3,3,6-trimethyl-2,3-dihydro-1 H-inden-5-yloxy)thiazole-4-carboxamide
2-(5-tert-butyl-2-methylphenoxy)-N-(4,6-dimethoxy-2-(2-oxoimidazolidin-1 -yl)pyrimidin-5-yl)oxazolθ-4-carboxamide
2-(5-tert-butyl-2-methylphenoxy)-N-(4,6-dimethoxy-2-(2-oxoimidazolidin-1-yl)pyrimidin-5-yl)thiazole-4-carboxamide N-(2-(2-tert-butoxyethoxy)-4,6-dimethoxypyrimidin-5-yl)-2-(5-tert-butyl-2-methylphenoxy)thiazole-4-carboxamide
2-(5-tert-butyl-2-methylphenoxy)-N-(2-(2-hydroxyethoxy)-4,6-dimethoxypyrimidin-5-yl)thiazole-4-carboxamide
2-(5-chloro-2-methylphenoxy)-N-(2-(2-hydroxyethylamino)-4,6-dimethoxypyrimidin-5-yl)thiazole-4-carboxamide
2-(2,5-dimethylphenoxy)-N1(2-(2-hydroxyethylamino)-4,6-dimethoxypyrimidin-5-yl)thiazole-4-carboxamide
N-(2-(2-hydroxyethylamino)-4,6-dimethoxypyrimidin-5-yl)-2-(o-tolyloxy)thiazole-4-carboxamide
2-(2-chloro-5-(trifluoromethyl)phenoxy)-N-(2-(2-hydroxyethylamino)-4,6-dimethoxypyrimidin-5-yl)thiazole-4-carboxamide
2-(6-bromo-3,3-dimethyl-2,3-dihydro-1 H-inden-5-yloxy)-N-(2-(2-(isopropylamino)ethylamino)-4,6-dimethoxypyrimidin-5-yl)thiazole-4-carboxamide
2-(6-chloro-3,3-dimethyl-2,3-dihydro-1 H-inden-5-yloxy)-N-(2-(2-(isopropylamino)θthylamino)-4,6-dimethoxypyrimidin-5-yl)thiazole-4-carboxamide
N-(2-(2-(isopropylamino)ethylamino)-4,6-dimethoxypyrimidin-5-yl)-2-(6-methoxy-3,3-dimethyl-2,3-dihydro-1 H-inden-5-yloxy)thiazole-4-carboxamide
N-(2-(2-(isopropylamino)ethylamino)-4,6-dimethoxypyrinnidin-5-yl)-2-(5-methoxy-2-methylphenoxy)thiazole-4-carboxamide
2-(2-bromo-5-tert-butylphenoxy)-N-(2-(2-(isopropylamino)ethylamino)-4,6-dimethoxypyrimidin-5-yl)thiazole-4-carboxamide
2-(5-tert-butyl-2-methoxyphenoxy)-N-(2-(2- (isopropylamino)ethylamino)-4,6-dimethoxypyrimidin-5-yl)thiazole-4-carboxamide
2-(5-bromo-2-methylphenoxy)-N-(2-(2-(isopropylamino)ethylamino)-4,6-dimethoxypyrimidin-5-yl)thiazole-4-carboxamide
2-(4-chloro-5-isopropyl-2-methylphenoxy)-N-(2-(2- (isopropylamino)ethylamino)-4,β-dimethoxypyrimidin-5-yl)thiazolθ-4-carboxamide
2-(2-tert-butylphenoxy)-N-(2-(2-(isopropylamino)ethylamino)-4,6-dimethoxypyrimidin-5-yl)thiazole-4-carboxamide N-(2-(2-(isopropylamino)θthylamino)-4,6-climethoxypyrimidin-5-yl)-2-(2-methyl-5-propoxyphenoxy)thiazole-4-carboxamide
2-(5-isopropoxy-2-methylphenoxy)-N-(2-(2-(isopropylamino)ethylamino)-4,6-dimethoxypyrimiclin-5-yl)thiazole-4-carboxamide
2-(5-ethoxy-2-methylphenoxy)-N-(2-(2-(isopropylamino)ethylamino)-4,6-dimethoxypyrimidin-5-yl)thiazole-4-carboxamide
2-(5-isobutoxy-2-methylphenoxy)-N-(2-(2-(isopropylamino)ethylamino)-4,6-dimethoxypyrimidin-5-yl)thiazole-4-carboxamide
N-(2-(2-hydroxyethylamino)-4,6-dimethoxypyrimidin-5-yl)-2-(2-methyl- 5-(2-morpholinoethoxy)phenoxy)thiazole-4-carboxamide
tert-butyl 4-(4,6-dimethoxy-5-(2-(3,3,6-trimethyl-2,3-dihydro-1 H-inden-5-yloxy)thiazole-4-carboxamido)pyrimidin-2-yl)piperazine-1-carboxylate
N-(4,6-dimethoxy-2-(piperazin-1 -yl)pyrimidin-5-yl)-2-(3,3,6-trimethyl-2,3-dihydro-1 H-inden-5-yloxy)thiazole-4-carboxamide
tert-butyl 4-(4,6-dimethoxy-5-(2-(3,3,6-trimethyl-2,3-dihydro-1 H-inden-5-yloxy)thiazole-4-carboxamido)pyrimidin-2-yl)-1 ,4-diazepane-1 -carboxylate

N-(2-(1 ,4-diazepan-1 -yl)-4,6-dimethoxypyrimidin-5-yl)-2-(3,3,6-trimethyl-2,3-dihydro-1 H-inden-5-yloxy)thiazole-4-carboxamide
tert-butyl 2-((4,6-dimethoxy-5-(2-(3,3,6-trimethyl-2,3-dihydro-1 H-inden- 5-yloxy)thiazole-4-carboxamido)pyrimidin-2-ylamino)methyl)pyrrolidine-1 -carboxylate
N-(4,6-dimethoxy-2-(pyrrolidin-2-ylmethylamino)pyrimidin-5-yl)-2-(3,3,6-trimethyl-2,3-dihydro-1 H-inden -5-yloxy)thiazole-4-carboxamide
2-(5-tert-butyl-2-cyanophenoxy)-N-(2-(2-(isopropylamino)ethylamino)- 4,6-dimethoxypyrimidin-5-yl)thiazole-4-carboxamide
2-(5-(2-hydroxypropan-2-yl)-2-methylphenoxy)-N-(2-(2-(isopropylamino)ethylamino)-4,6-dimethoxypyrimidin-5-yl)thiazole-4-carboxamide
N-(2-((1 H-imidazol-2-yl)methylamino)-4,6-dimethoxypyrimidin-5-yl)-2- (5-tert-butyl-2-methylphenoxy)thiazole-4-carboxamide
2-(5-tert-butyl-2-chlorophenoxy)-N-(2-(2-(isopropylamino)ethylamino)-4,6-dimethoxypyrimidin-5-yl)thiazole-4-carboxamidθ 5-(5-tert-butyl-2-methylphenoxy)-N-(2-(2-(isopropylamino)ethyIamino)-4,6-dimethoxypyrimidin-5-yl)-4-methyl-4H-1 ,2,4-triazole-3-carboxamide
5-(3-tert-butylphenoxy)-N-(2-(2-(isopropylamino)ethylamino)-4,6-dimethoxypyrimidin-5-yl)-4-methyl-4H-1 ,2,4-triazole-3-carboxamide
2-(5-tert-butyl-2-methylphenoxy)-N-(4,6-dimethoxy-2-(morpholin-2-ylmethylamino)pyrimidin-5-yl)thiazole-4-carboxamide
N-(2-(2-(N-(bis(dimethylamino)methylene)sulfamoyl)ethylamino)-4,6-dimethoxypyrimidin-5-yl)-2-(5-tert-butyl-2-methylphenoxy)thiazole-4-carboxamide
2-(5-tert-butyl-2-methylphenoxy)-N-(2-(2-cyanoethylamino)-4,6-dimethoxypyrimidin-5-yl)thiazolθ-4-carboxamide
3-(5-(2-(5-tert-butyl-2-methylphenoxy)thiazole-4-carboxamido)-4,6-dimethoxypyrimidin-2-ylannino)propanoic acid
2-(5-tert-butyl-2-methylphenoxy)-N-(2-(2-(N-isopropylsulfamoyl)ethylamino)-4,6-dimethoxypyrimidin-5-yl)thiazole-4-carboxamidθ
N-(2-(3-amino-3-oxopropylamino)-4,6-dimethoxypyrimidin-5-yl)-2-(5-tert-butyl-2-methylphenoxy)thiazole-4-carboxamide
2-(5-tert-butyl-2-methylphenoxy)-N-(2-(2-(ethylamino)ethoxy)-4,6-dimethoxypyrimidin-5-yl)thiazole-4-carboxamide
2-(5-tert-butyl-2-methylphenoxy)-N-(2-(2-(isopropoylamino)ethoxy)-4,6-dimethoxypyrimidin-5-yl)thiazole-4-carboxamide
2-(5-tert-butyl-2-methylphenoxy)-N-(2-(3-(ethylamino)propyl)-4,6-dimethoxypyrimidin-5-yl)thiazole-4-carboxamide
2-(5-tert-butyl-2-methylphenoxy)-N-(2-(3-(isopropylamino)propyl)-4,6-dimethoxypyrimidin-5-yl)thiazole-4-carboxamide
2-(5-tert-butyl-2-methylphenoxy)-N-(2-(3-(ethylamino)propylamino)-4,6-dimθthoxypyrimidin-5-yl)thiazole-4-carboxamidθ
2-(5-tert-butyl-2-methylphenoxy)-N-(2-(3-(isopropylamino)propylamino)-4,6-dimethoxypyrimidin-5-yl)thiazole-4-carboxamidθ
2-(5-tert-butyl-2-methylphenoxy)-N-(2-(3-(ethylamino)propoxy)-4,6-dimethoxypyrimidin-5-yl)thiazole-4-carboxamide 2-(5-tert-butyl-2-methyiphenoxy)-N-(2-(3-(isopropylamino)propoxy)-4,6-dimethoxypyrimidin-5-yl)thiazole-4-carboxamicle
2-(5-tert-butyl-2-methylphenoxy)-N-(2-(4-(ethylamino)butyl)-4,6-dimethoxypyrimidin-5-yl)thiazole-4-carboxamicie; and
2-(5-tert-butyl-2-methylphenoxy)-N-(2-(4-(isopropylamino)butyl)-4,6-dimethoxypyrimidin-5-y!)thiazole-4-carboxamide.
15. A compound according to any preceding claim, which is chiral and is in the form of a single enantiomer or diastereomer.
16. A compound according to any preceding claim, for therapeutic use. 17. A pharmaceutical composition comprising a compound of any of claims 1 to 15 and a pharmaceutically acceptable diluent or carrier.
18. Use of a compound of any of claims 1 to 15, for the manufacture of a medicament for cancer therapy.
19. Use of a compound according to any of claims 1 to 15, for the manufacture of a medicament for the treatment or prevention of endometriosis, uterine myoma, an ovarian disease, a mammary cystic disease, prostatic hypertrophy, amenorrhoea, precocious puberty, premenstrual syndrome, a sex-steroid-dependent pathophysiology or benign prostatic hyperplasia, or to arrest spermatogenesis.
20. Use according to claim 19, for the treatment or prevention of endometriosis with pain, polycystic ovarian disease or secondary amenorrhoea.
21. Use of a compound according to any of claims 1 to 15, for the manufacture of a medicament for the treatment or prevention of Alzheimer's disease.
22. Use of a compound according to any of claims 1 to 15, for the manufacture of a medicament for the treatment or prevention of HIV infection or AIDS.
23. Use of a compound according to according to any of claims 1 to 15, for the manufacture of a medicament for the treatment or prevention of a disease caused by thymic malfunction.
24. Use according to claim 23, for the treatment or prevention of multiple sclerosis, rheumatoid arthritis or type 1 diabetes.