Processing

Please wait...

Settings

Settings

Goto Application

1. WO2006128190 - COMPOSITIONS AND METHODS FOR TREATMENT OF NEURAL DISORDERS USING TRANSFORMING GROWTH FACTOR-BETA SUPERFAMILY PROTEINS AND THEIR ANTAGONISTS

Publication Number WO/2006/128190
Publication Date 30.11.2006
International Application No. PCT/US2006/021016
International Filing Date 30.05.2006
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
CPC
A61K 38/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
18Growth factors; Growth regulators
Applicants
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US]/[US] (AllExceptUS)
  • CALOF, Anne, L. [US]/[US] (UsOnly)
  • KIM, Joon [KR]/[US] (UsOnly)
  • KAWAUCHI, Shimako [US]/[US] (UsOnly)
Inventors
  • CALOF, Anne, L.
  • KIM, Joon
  • KAWAUCHI, Shimako
Agents
  • FESSENMAIER, Martin
Priority Data
60/685,63027.05.2005US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITIONS AND METHODS FOR TREATMENT OF NEURAL DISORDERS USING TRANSFORMING GROWTH FACTOR-BETA SUPERFAMILY PROTEINS AND THEIR ANTAGONISTS
(FR) COMPOSITIONS ET PROCEDES POUR LE TRAITEMENT DE TROUBLES NEURONAUX FAISANT APPEL A DES PROTEINES DE LA SUPERFAMILLE TGF-BETA ET A LEURS ANTAGONISTES
Abstract
(EN)
Contemplated compositions and methods employ a TGF-beta superfamily protein or antagonist thereof to treat a neural disorder characterized by an imbalance in differentiated functional sensory and neural cells derived from a sensory/neural progenitor cell. Preferably, GDF-11 and/or antagonists thereof are employed in the treatment of diseases in which visual and/or auditory progenitor cells will provide for a repair mechanism to the disease. Most preferably, GDF-11 is employed as a modulator of competency to increase production of retinal ganglion cells, retinal photoreceptors, retinal amacrine cells, sensory hair and supporting cells of the vestibulocochlear epithelium, and/or neurons and supporting cells of the spiral acoustic ganglion and vestibulo-cochlear (auditory) nerve to which it gives rise.
(FR)
Compositions et procédés faisant appel à une protéine de superfamille TGF-bêta ou un antagoniste, pour le traitement de trouble neuronal caractérisé par un déséquilibre de cellules sensorielles et neuronales différenciées dérivées d'une cellule progénitrice sensorielle/neuronale. De préférence, utilisation de GDF-11 et/ou d'antagonistes dans le traitement de maladies pour lesquelles des cellules progénitrices de la vue et/ou de l'audition constituent un mécanisme de réparation vis-à-vis de la maladie. De préférence encore, utilisation de GDF-11 comme modulateur de compétence pour augmenter la production de cellules ganglionnaires de la rétine, photorécepteurs rétiniens, cellules amacrines de la rétine, cils sensoriels et cellules supports de l'épithélium vestibulo-cochléaire, et/ou neurones et cellules supports du ganglion spiral acoustique et du nerf (auditif) vestibulo-cochléaire qui en est issu..
Also published as
EP6771662
Latest bibliographic data on file with the International Bureau