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1. (WO2006128163) TRANSGENIC ALZHEIMER'S MOUSE MODEL VECTORS AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/128163    International Application No.:    PCT/US2006/020899
Publication Date: 30.11.2006 International Filing Date: 26.05.2006
IPC:
C12Q 1/02 (2006.01), C12N 15/00 (2006.01), C12N 5/00 (2006.01), C12N 5/08 (2006.01), C07K 1/00 (2006.01), C07H 21/04 (2006.01), G01N 33/00 (2006.01), A01K 67/00 (2006.01)
Applicants: MEMORY PHARMACEUTICALS CORP. [US/US]; 100 Philips Parkway, Montvale, NJ 07645 (US) (For All Designated States Except US).
DE VIVO, Michael [US/US]; (US) (For US Only).
HEYER, Joerg, August, Konrad [DE/US]; (US) (For US Only).
KWAN, Mei, Yee [CA/US]; (US) (For US Only).
WANG, Daguang [US/US]; (US) (For US Only).
XIAO, Qiurong [US/US]; (US) (For US Only)
Inventors: DE VIVO, Michael; (US).
HEYER, Joerg, August, Konrad; (US).
KWAN, Mei, Yee; (US).
WANG, Daguang; (US).
XIAO, Qiurong; (US)
Agent: BUCK, Margaret, M.; Lowenstein Sandler PC, 65 Livingston Avenue, Roseland, NJ 07068 (US)
Priority Data:
60/685,649 27.05.2005 US
Title (EN) TRANSGENIC ALZHEIMER'S MOUSE MODEL VECTORS AND USES THEREOF
(FR) VECTEURS DE MODELES DE SOURIS TRANSGENIQUES ALZHEIMER ET LEURS UTILISATIONS
Abstract: front page image
(EN)The present invention provides for a recombinant nucleic acid molecule comprising a humanized mouse /3-amyloid precursor protein ('APP') gene comprising K670N, M671L and V717F mutations and uses thereof. The present invention further provides for a recombinant nucleic acid molecule comprising a region of a calcium-calmodurin dependent kinase Il&agr; ('CaMKIIa') promoter operatively linked to a /3-amyloid precursor protein ('APP') gene comprising at least one mutation and uses thereof.
(FR)L'invention concerne une molécule d'acide nucléique recombinante comprenant un gène de protéine précurseur de 3-amyloïde (APP) / souris humanisée comprenant les mutations K670N, M671L et V717F, et ses utilisations. L'invention concerne également une molécule d'acide nucléique recombinante comprenant une zone de promoteur de kinase II$g(a) calcium/calmodurine dépendante (CaMKIIa) fonctionnellement reliée à un gène de protéine précurseur de 3-amyloïde (APP) comprenant au moins une mutation. L'invention concerne également des utilisations de cette molécule.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)