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1. (WO2006128063) METHODS AND COMPOSITIONS FOR INHIBITING GLIOMA GROWTH
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/128063    International Application No.:    PCT/US2006/020621
Publication Date: 30.11.2006 International Filing Date: 25.05.2006
IPC:
C07K 16/30 (2006.01), C12N 15/11 (2006.01), G01N 33/50 (2006.01)
Applicants: IRM LLC [US/US]; Hurst Holme, 12 Trott Road, Hamilton, HM 11 (BM) (For All Designated States Except US).
GAO, Xiaoqi [CA/US]; (US) (For US Only).
CHAO, Sheng-Hao [CN/US]; (US) (For US Only).
CALDWELL, Jeremy, Scot [US/US]; (US) (For US Only)
Inventors: GAO, Xiaoqi; (US).
CHAO, Sheng-Hao; (US).
CALDWELL, Jeremy, Scot; (US)
Agent: WANG, Hugh; Genomics Institute Of The Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121 (US)
Priority Data:
60/684,352 25.05.2005 US
Title (EN) METHODS AND COMPOSITIONS FOR INHIBITING GLIOMA GROWTH
(FR) METHODES ET COMPOSITIONS POUR INHIBER LA CROISSANCE DES GLIOMES
Abstract: front page image
(EN)This invention provides cellular factors that positively regulate glioma growth. The invention provides methods and pharmaceutical compositions for inhibiting glioma growth and treating gliomas in human or non-human subjects. The invention also provides methods of screening for novel compounds that inhibit glioma growth. In particular, the invention provides the use of siRNA. miRNA, shRNA, anti sense nucleic acid, cDNA and antibodies against the positive growth regulators of glioma selected from CDC25B, NEK 9, KIAA 0703, ABL 1, ING 4 and CBLC.
(FR)L'invention concerne des facteurs cellulaires qui régulent positivement la croissance des gliomes. L'invention concerne également des méthodes et des compositions pharmaceutiques permettant d'inhiber la croissance des gliomes et de traiter des gliomes chez des sujets humains ou non humains. L'invention concerne enfin des méthodes de criblage de nouveaux composés qui inhibent la croissance des gliomes.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)