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1. (WO2006128012) TWIN ARGININE TRANSLOCASE SECRETORY APPARATUS: HIGH THROUGHPUT ASSAYS AND VACCINE VECTORS RELATED THERETO
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/128012    International Application No.:    PCT/US2006/020486
Publication Date: 30.11.2006 International Filing Date: 24.05.2006
IPC:
G01N 33/573 (2006.01), G01N 33/554 (2006.01), G01N 33/00 (2006.01)
Applicants: THE REGENTS OF THE UNIVERSITY OF COLORADO [US/US]; 201 Regent Administrative Center, 3 SYS, Boulder, CO 80309 (US) (For All Designated States Except US).
VASIL, Michael, L. [US/US]; (US) (For US Only).
VASIL, Adriana, I. [US/US]; (US) (For US Only).
OCHSNER, Urs, A. [CH/US]; (US) (For US Only).
SNYDER, Aleksandra [US/US]; (US) (For US Only)
Inventors: VASIL, Michael, L.; (US).
VASIL, Adriana, I.; (US).
OCHSNER, Urs, A.; (US).
SNYDER, Aleksandra; (US)
Agent: SEBOR, Angela, Dallas; SHERIDAN ROSS P.C., 1560 Broadway, Suite 1200, Denver, CO 80202-5141 (US)
Priority Data:
60/684,489 24.05.2005 US
Title (EN) TWIN ARGININE TRANSLOCASE SECRETORY APPARATUS: HIGH THROUGHPUT ASSAYS AND VACCINE VECTORS RELATED THERETO
(FR) APPAREIL DE SECRETION D'ARGININE TRANSLOCASE DOUBLE : DOSAGES DE HAUT RENDEMENT ET VECTEURS DE VACCIN ASSOCIES
Abstract: front page image
(EN)Disclosed are high throughput assays for the identification of specific inhibitors of the twin arginine translocase secretory apparatus. Also disclosed are bacterial twin arginine translocase mutants for use as vaccines, vaccine vectors or vehicles for the delivery of therapeutic agents, and to prophylactic and therapeutic immunization and treatment methods using such vaccines, vectors and delivery vehicles.
(FR)La présente invention concerne des dosages de haut rendement permettant d'identifier les inhibiteurs spécifiques de l'appareil de sécrétion d'arginine translocase double. Cette invention concerne aussi des mutants d'arginine translocase double bactériens destinés à être utilisé comme vaccins, des vecteurs de vaccins ou des véhicules permettant d'apporter des agents thérapeutiques et, l'immunisation prophylactique et thérapeutique ainsi que des techniques de traitement utilisant ces vaccins, ces vecteurs et ces véhicules d'apport..
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)