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Machine translation
1. (WO2006127926) CRYSTALLINE AND OTHER FORMS OF 4-AMINO-5-FLUORO-3-[6-(4-METHYLPIPERAZIN-1-YL)-1H-BENZIMIDAZOL-2-YL]-1H-QUINOLIN-2-ONE LACTIC ACID SALTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/127926    International Application No.:    PCT/US2006/020296
Publication Date: 30.11.2006 International Filing Date: 23.05.2006
IPC:
C07D 401/14 (2006.01), A61K 31/496 (2006.01)
Applicants: NOVARTIS AG [CH/CH]; Lichtstrasse 35, CH-4056 Basel (CH) (For All Designated States Except US).
OKHAMAFE, Augustus [US/US]; (US) (For US Only).
CHOU, Joyce [US/US]; (US) (For US Only).
GULLAPALLI, Rampurna [US/US]; (US) (For US Only).
HARWOOD, Eric [US/US]; (US) (For US Only).
RYCKMAN, David [US/US]; (US) (For US Only).
ZHU, Shuguang [CA/US]; (US) (For US Only).
SHANG, Xiao [CA/US]; (US) (For US Only)
Inventors: OKHAMAFE, Augustus; (US).
CHOU, Joyce; (US).
GULLAPALLI, Rampurna; (US).
HARWOOD, Eric; (US).
RYCKMAN, David; (US).
ZHU, Shuguang; (US).
SHANG, Xiao; (US)
Agent: GODDARD, Christine, A.; Fish & Richardson P.C., P.O. Box 1022, Minneapolis, MN 55440-1022 (US)
Priority Data:
60/683,999 23.05.2005 US
Title (EN) CRYSTALLINE AND OTHER FORMS OF 4-AMINO-5-FLUORO-3-[6-(4-METHYLPIPERAZIN-1-YL)-1H-BENZIMIDAZOL-2-YL]-1H-QUINOLIN-2-ONE LACTIC ACID SALTS
(FR) FORMES CRISTALLINE ET AUTRES DE SELS D'ACIDE LACTIQUE 4-AMINO-5-FLUORO-3-[6-(4-METHYLPIPERAZIN-1-YL)-1H-BENZIMIDAZOL-2-YL]-1H-QUINOLIN-2-ONE
Abstract: front page image
(EN)The present invention relates to non-hydrate crystalline forms of 4-amino- 5-fluoro-3 -[6-(4-methylpiperazin- 1 -yl)- 1 H-benzimidazol-2-yl] - 1 H-quinolin-2-one lactic acid salts, solid pharmaceutical formulations containing the same and methods of use. The present invention also relates to crystalline hydrates of 4-arnino-5-fiuoro-3-[6-(4- methylpiperazin-l-yl)-lH-benzimidazol-2-yl]-lH-quinolin-2-one lactic acid salts, pharmaceutical formulations containing the same and methods of use related thereto. The present invention further relates to crystalline solvates of 4-amino-5-fluoro-3-[6-(4- methylpiperazin-l-yl)-lH-benzimidazol-2-yl]-lH-quinolin-2-one lactic acid salts.
(FR)La présente invention concerne des formes cristallines non hydratées de sels d'acide lactique 4-amino- 5-fluoro-3 -[6-(4-méthylpipérazin- 1 -yl)- 1 H-benzimidazol-2-yl] - 1 H-quinolin-2-one, des formulations pharmaceutiques les contenant et des procédés de leur utilisation. La présente invention concerne aussi des hydrates cristallins de sels d'acide lactique 4-amino-5-fiuoro-3-[6-(4- méthylpipérazin-l-yl)-lH-benzimidazol-2-yl]-lH-quinolin-2-one, des formulations pharmaceutiques les contenant et des procédés de leur utilisation. La présente invention concerne aussi des solvates cristallins de sels d'acide lactique 4-amino-5-fluoro-3-[6-(4- méthylpipérazin-l-yl)-lH-benzimidazol-2-yl]-lH-quinolin-2-one.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)