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1. (WO2006127607) PI3K PATHWAY MUTATIONS IN CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/127607    International Application No.:    PCT/US2006/019748
Publication Date: 30.11.2006 International Filing Date: 23.05.2006
IPC:
C40B 30/06 (2006.01)
Applicants: THE JOHNS HOPKINS UNIVERSITY [US/US]; 100 N. CHARLES STREET, 5th Floor, Baltimore, MD 21201 (US) (For All Designated States Except US).
PARSONS, Donald, William [US/US]; (US) (For US Only).
WANG, Tian-li. Ph.D. [US/US]; (US) (For US Only).
SAMUELS, Yardena [IL/US]; (US) (For US Only).
BARDELLI, Alberto [IT/IT]; (IT) (For US Only).
LENGAUER, Christopher [AT/US]; (US) (For US Only).
VELCULESCU, Victor [US/US]; (US) (For US Only).
KINZLER, Kenneth, W. [US/US]; (US) (For US Only).
VOGELSTEIN, Bert [US/US]; (US) (For US Only)
Inventors: PARSONS, Donald, William; (US).
WANG, Tian-li. Ph.D.; (US).
SAMUELS, Yardena; (US).
BARDELLI, Alberto; (IT).
LENGAUER, Christopher; (US).
VELCULESCU, Victor; (US).
KINZLER, Kenneth, W.; (US).
VOGELSTEIN, Bert; (US)
Agent: KAGAN, Sarah, A.; BANNER & WITCOFF, LTD., 1001 G. STREET, N.W., 11th Floor, Washington, DC 20001-4597 (US)
Priority Data:
60/683,738 23.05.2005 US
Title (EN) PI3K PATHWAY MUTATIONS IN CANCER
(FR) MUTATION DE VOIE PI3K DANS LE CANCER
Abstract: front page image
(EN)Given the important role of protein kinases in pathways affecting cellular growth and invasion, we have analyzed 340 serine/threonine kinases for genetic mutations in colorectal cancers. Mutations in eight genes were identified, including three members of the phosphatidylinositol-3- kinase (PI3K) pathway; the alterations in the latter genes each occurred in different tumors and did not overlap with mutations in PIK3CA or other non-serine-threonine kinase (STK) members of the PI3K pathway, suggesting that mutations in any of these genes had equivalent tumorigenic effects. These data demonstrate that the PI3K pathway is a major target for mutational activation in colorectal cancers and provide new opportunities for therapeutic intervention.
(FR)Etant donné le rôle important des protéines kinases dans les voies affectant la croissance et l'invasion cellulaires, on a analysé 340 sérine/thréonine kinases à la recherche de mutation génétiques dans des cancers colorectaux. Des mutations ont été identifiées au niveau de huit gènes, notamment trois membres de la phosphatidylinositol-3-kinase (PI3K) ; les modifications au niveau de ces derniers gènes se sont chacune produites dans différentes tumeurs et ne se sont pas chevauchées avec les mutations au niveau de PIK3CA ou autres membres de non-sérine-thréonine kinase (STK) de la voie PI3K, suggérant que des mutations dans n'importe lequel desdits gènes présente des effets tumorigènes équivalents. Lesdites données démontrent que la voie PI3K est une cible majeure pour l'activation mutationnelle dans des cancers colorectaux et assurent de nouvelles opportunités pour une intervention thérapeutique.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)