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1. (WO2006127584) IMIDAZOLONE PHENYLALANINE DERIVATIVES AS VLA-4 ANTAGONISTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/127584    International Application No.:    PCT/US2006/019708
Publication Date: 30.11.2006 International Filing Date: 22.05.2006
IPC:
C07D 471/04 (2006.01), A61K 31/437 (2006.01), A61K 31/444 (2006.01), A61K 31/506 (2006.01), A61P 29/00 (2006.01)
Applicants: ELAN PHARMACEUTICALS, INC. [US/US]; 800 Gateway Blvd., South San Francisco, CA 94080 (US) (For All Designated States Except US).
STAPPENBECK, Frank [US/US]; (US) (For US Only).
KONRADI, Andrei [US/US]; (US) (For US Only).
JAGODZINSKI, Jacek [US/US]; (US) (For US Only).
SEMKO, Christopher, M. [US/US]; (US) (For US Only).
XU, Ying-zi [US/US]; (US) (For US Only).
SMITH, Jenifer, L. [US/US]; (US) (For US Only).
ROSSITER, Kassandra [US/US]; (US) (For US Only)
Inventors: STAPPENBECK, Frank; (US).
KONRADI, Andrei; (US).
JAGODZINSKI, Jacek; (US).
SEMKO, Christopher, M.; (US).
XU, Ying-zi; (US).
SMITH, Jenifer, L.; (US).
ROSSITER, Kassandra; (US)
Agent: SARUSSI, Steven, J.; MCDONNELL BOEHNEN HULBERT & BERGHOFF LLP, 300 South Wacker Drive, Suite 3200, Chicago, IL 60606 (US)
Priority Data:
60/683,509 20.05.2005 US
Title (EN) IMIDAZOLONE PHENYLALANINE DERIVATIVES AS VLA-4 ANTAGONISTS
(FR) DERIVES D'IMIDAZOLONE PHENYLALANINE UTILISES COMME ANTAGONISTES DE VLA-4
Abstract: front page image
(EN)Disclosed are compounds of the f ormula : and the pharmaceutically acceptable salts thereof wherein the variables A, n, R5, R21-R24 and Q are defined herein. These compounds bind VLA-4. Certain of these compound also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
(FR)L'invention concerne des composés de formule (I) et des sels pharmaceutiquement acceptables de ces composés. Dans cette formule, les variables A, n, R5, R21-R24 et Q sont telles que définies dans la description. Ces composés se lient à VLA-4. En outre, certains desdits composés inhibent l'adhésion leucocytaire, et plus particulièrement l'adhésion leucocytaire médiée par VLA-4. Ces composés sont utiles dans le traitement de maladies inflammatoires chez un mammifère tel qu'un être humain, et notamment dans le traitement de l'asthme, de la maladie d'Alzheimer, de l'athérosclérose, de la démence du SIDA, du diabète, de l'affection abdominale inflammatoire, de l'arthrite rhumatoïde, d'une affection liée à une greffe de tissu, de la métastase tumorale et de l'ischémie myocardique. Lesdits composés peuvent également être administrés pour traiter des maladies neurologiques inflammatoires telles que la sclérose en plaques.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)