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1. (WO2006127205) METHODS OF PREPARING 3-CYANO-QUINOLINES AND INTERMEDIATES MADE THEREBY

Pub. No.:    WO/2006/127205    International Application No.:    PCT/US2006/016019
Publication Date: Nov 30, 2006 International Filing Date: Apr 27, 2006
IPC: C07C 251/50
C07D 209/48
C07D 213/30
C07D 215/54
C07D 401/12
Applicants: WYETH
CHEW, Warren
PAPAMICHELAKIS, Maria
Inventors: CHEW, Warren
PAPAMICHELAKIS, Maria
Title: METHODS OF PREPARING 3-CYANO-QUINOLINES AND INTERMEDIATES MADE THEREBY
Abstract:
The present invention relates to methods for preparing substituted 3-cyanoquinolines and intermediates obtained by the methods of the present invention. The methods of the invention comprise reacting an N-aryl-2-propanimide with phosphoryl chloride to produce the substituted 3-cyanoquinolines. The methods further comprise reacting arylamines, orthoformates and active methylenes to produce the N-aryl-2-propenamide.