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Machine translation
1. (WO2006127180) A PROCESS FOR PREPARING (2R,3S)-1,2-EPOXY-3-(PROTECTED)AMINO-4-SUBSTITUTED BUTANE AND INTERMEDIATES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/127180    International Application No.:    PCT/US2006/014629
Publication Date: 30.11.2006 International Filing Date: 19.04.2006
IPC:
C12P 13/00 (2006.01), C07K 14/48 (2006.01)
Applicants: BRISTOL-MYERS SQUIBB COMPANY [US/US]; Route 206 And Province Line Road, Princeton, New Jersey 08543-4000 (US) (For All Designated States Except US).
BOWERS, Nigel, Ian [IE/US]; (US) (For US Only).
SKONEZNY, Paul, M. [US/US]; (US) (For US Only).
STEIN, Gregory, L. [US/US]; (US) (For US Only).
FRANCESCHINI, Thomas [US/US]; (US) (For US Only).
CHIANG, Shu-Jen [US/US]; (US) (For US Only).
ANDERSON, Wendy, L. [US/US]; (US) (For US Only).
YOU, Li [US/US]; (US) (For US Only).
XING, Zizhuo [US/US]; (US) (For US Only)
Inventors: BOWERS, Nigel, Ian; (US).
SKONEZNY, Paul, M.; (US).
STEIN, Gregory, L.; (US).
FRANCESCHINI, Thomas; (US).
CHIANG, Shu-Jen; (US).
ANDERSON, Wendy, L.; (US).
YOU, Li; (US).
XING, Zizhuo; (US)
Agent: COHEN, Jacqueline, M.; Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, New Jersey 08543-4000 (US)
Priority Data:
60/684,300 25.05.2005 US
11/365,275 01.03.2006 US
Title (EN) A PROCESS FOR PREPARING (2R,3S)-1,2-EPOXY-3-(PROTECTED)AMINO-4-SUBSTITUTED BUTANE AND INTERMEDIATES THEREOF
(FR) PROCEDE POUR PREPARER DU BUTANE (2R,3S)-1,2-EPOXY-3-(PROTEGE)AMINO-4-SUBSTITUE ET DES INTERMEDIAIRES DE CELUI-CI
Abstract: front page image
(EN)The present invention relates to a process for preparing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane comprising contacting a mutagenized Rhodococcus erythropolis having ATCC deposit no. PTA-6648 with (3S)-1-halo-2-oxo-3-(protected)amino-4-substituted butane substrate. The present invention also relates to a process comprising mixing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane with at least one base in the presence of at least one solvent to produce a reaction mixture containing (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane. The present invention further relates to a process comprising crystallizing the (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane out of the reaction mixture by concurrently adding water and the reaction mixture together. The present invention is also directed to a mutagenized Rhodococcus erythropolis having ATCC deposit no. PTA-6648.
(FR)La présente invention concerne un procédé pour préparer du butane (2R,3S)-1-halo-2-hydroxy-3-(protégé)amino-4-substitué, comprenant la mise en contact d'un Rhodococcus erythropolis mutagénisé ayant un dépôt ATCC no. PTA-6648 avec un substrat de butane (3S)-1-halo-2-oxo-3-(protégé)amino-4-substituté. L'invention a également pour objet un procédé comprenant le mélange de butane (2R,3S)-1-halo-2-hydroxy-3-(protégé)amino-4-substituté avec au moins une base, en la présence d'au moins un solvant, pour produire un mélange réactionnel contenant du butane (2R,3S)-1,2-époxy-3-(protégé)amino-4-substituté. L'invention concerne aussi un procédé comprenant la cristallisation du butane (2R,3S)-1,2-époxy-3-(protégé)amino-4-substituté, hors du mélange réactionnel, par adjonction simultanée d'eau et du mélange réactionnel. L'invention se rapporte également à un Rhodococcus erythropolis mutagénisé ayant un dépôt ATCC no. PTA-6648.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)