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1. WO2006126747 - MATRIX METALLOPROTEINASE-9 INHIBITOR CONTAINING CHLOROGENIC ACID

Publication Number WO/2006/126747
Publication Date 30.11.2006
International Application No. PCT/KR2005/001487
International Filing Date 23.05.2005
IPC
A61K 31/216 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
216of acids having aromatic rings, e.g. benactizyne, clofibrate
A61K 31/19 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19Carboxylic acids, e.g. valproic acid
CPC
A61K 31/216
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
216of acids having aromatic rings, e.g. benactizyne, clofibrate
Applicants
  • KIM, Cheorl-Ho [KR]/[KR]
Inventors
  • KIM, Cheorl-Ho
Agents
  • WONJON PATENT FIRM
Priority Data
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) MATRIX METALLOPROTEINASE-9 INHIBITOR CONTAINING CHLOROGENIC ACID
(FR) INHIBITEUR DE METALLOPROTEINASE-9 MATRICIELLE CONTENANT UN ACIDE CHLOROGENIQUE
Abstract
(EN) This invention is related to an MMP- 9 inhibitor which contains chlorogenic acid (CHA; 5-caffeoylquinic acid). Matrix metalloproteinase-9 inhibitors represent the best candidates for achieving tumor regression. Thus the invention is disclosed a chlorogenic acid, especially isolated from the Euonymus alatus, having a anti-MMP-9 activity. CHA showed strong inhibitory effect of MMP-9 activity in a concentration-dependent manner. The CHA showed cytotoxic effect on the hepatocarcinoma cellular proliferation and cell viability.
(FR) La présente invention concerne un inhibiteur MMP-9 qui contient un acide chlorogénique (acide; 5-caffeoylquinique, CHA). Des inhibiteur de métalloprotéinase-9 matricielle représentent les meilleurs candidats pour obtenir une régression de tumeur. Cette invention concerne donc un acide chlorogénique, spécialement isolé de euonymus alatus, possédant une activité anti-MMP-9. CHA présente un puissant effet inhibiteur de l'activité MMP-9 d'une manière dépendant de la concentration. Le CHA présente en effet cytotoxique sur la prolifération cellulaire d'hépatocarcinome et sur la viabilité cellulaire.
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EP5740766This application is not viewable in PATENTSCOPE because the national phase entry has not been published yet or the national entry is issued from a country that does not share data with WIPO or there is a formatting issue or an unavailability of the application.
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