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1. (WO2006126723) GENETICALLY MODIFIED MICROORGANISM AND PROCESS FOR PRODUCTION OF MACROLIDE COMPOUND USING THE MICROORGANISM
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/126723    International Application No.:    PCT/JP2006/310835
Publication Date: 30.11.2006 International Filing Date: 24.05.2006
IPC:
C12N 15/09 (2006.01), C12N 1/21 (2006.01), C12P 17/08 (2006.01), C12R 1/465 (2006.01)
Applicants: EISAI R & D MANAGEMENT CO., LTD. [JP/JP]; 6-10, Koishikawa 4-chome, Bunkyo-ku, Tokyo 1128088 (JP) (For All Designated States Except US).
MERCIAN CORPORATION [JP/JP]; 5-8, Kyobashi 1-chome, Chuo-ku, Tokyo 1048305 (JP) (For All Designated States Except US).
MACHIDA, Kazuhiro [JP/JP]; (JP) (For US Only).
ARITOKU, Yasuhide [JP/JP]; (JP) (For US Only)
Inventors: MACHIDA, Kazuhiro; (JP).
ARITOKU, Yasuhide; (JP)
Agent: FURUYA, Satoshi; Hamacho-Hanacho Building 6th Floor, 2-17-8, Nihonbashi-Hamacho, Chuo-ku, Tokyo 1030007 (JP)
Priority Data:
2005-154114 26.05.2005 JP
Title (EN) GENETICALLY MODIFIED MICROORGANISM AND PROCESS FOR PRODUCTION OF MACROLIDE COMPOUND USING THE MICROORGANISM
(FR) MICROORGANISME GENETIQUEMENT MODIFIE ET PROCEDE POUR LA PRODUCTION D’UN COMPOSE MACROLIDE UTILISANT LE MICROORGANISME
(JA) 遺伝子組換え微生物およびそれらの微生物を用いるマクロライド系化合物の製造方法
Abstract: front page image
(EN)A genetically modified microorganism capable of directly producing a 16-hydroxylated macrolide compound; and a process for producing a 16-hydroxylated macrolide compound using the microorganism. Specifically, a genetically modified microorganisms having DNA encoding a polypeptide involved in the biosynthesis of a macrolide compound pladienolide and DNA encoding a polypeptide having a pladienolide 16-hydroxylase activity; and a process for producing a 16-hydroxylated macrolide compound comprising the steps of culturing the genetically modified microorganism in a culture medium and collecting a 16-hydroxylated macrolide compound from the culture medium.
(FR)Microorganisme génétiquement modifié capable de produire directement un composé macrolide 16-hydroxylé ; et procédé pour produire un composé macrolide 16-hydroxylé en utilisant le microorganisme. Spécifiquement, l’invention concerne des microorganismes génétiquement modifiés ayant un ADN codant pour un polypeptide impliqué dans la biosynthèse d’un composé macrolide pladiénolide et un ADN codant pour un polypeptide ayant une activité de 16-hydroxylase pladiénolide ; et un procédé pour produire un composé macrolide 16-hydroxylé comprenant les étapes de culture du microorganisme génétiquement modifié dans un milieu de culture et de récolte d’un composé macrolide 16-hydroxylé à partir du milieu de culture.
(JA)本発明は、16位水酸化マクロライド系化合物を直接生産する遺伝子組換え微生物、およびそれらの遺伝子組換え微生物を用いた16位水酸化マクロライド系化合物の製造方法を提供する。詳しくは、マクロライド系化合物プラジエノライドの生合成に関与するポリペプチドをコードするDNAおよびプラジエノライドの16位水酸化酵素活性を有するポリペプチドをコードするDNAを有する遺伝子組換え微生物、およびそれらの遺伝子組換え微生物を培地で培養し、その培養液から16位水酸化マクロライド系化合物を採取することを特徴とする、16位水酸化マクロライド系化合物の製造方法である。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)