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Pub. No.:    WO/2006/126267    International Application No.:    PCT/JP2005/009637
Publication Date: 30.11.2006 International Filing Date: 26.05.2005
C12N 15/87 (2006.01), A61K 48/00 (2006.01), A61N 7/00 (2006.01)
Applicants: MEBIOPHARM CO., LTD. [JP/JP]; 8-3-20, Akasaka, Minato-ku, Tokyo 1070052 (JP) (For All Designated States Except US).
MARUYAMA, Kazuo [JP/JP]; (JP) (For US Only).
TAKIZAWA, Tomoko [JP/JP]; (JP) (For US Only).
HAGISAWA, Kosuke [JP/JP]; (JP) (For US Only).
NISHIOKA, Toshihiko [JP/JP]; (JP) (For US Only).
YANAGIE, Hironobu [JP/JP]; (JP) (For US Only)
Inventors: MARUYAMA, Kazuo; (JP).
TAKIZAWA, Tomoko; (JP).
HAGISAWA, Kosuke; (JP).
NISHIOKA, Toshihiko; (JP).
YANAGIE, Hironobu; (JP)
Agent: THE PATENT CORPORATE BODY ARUGA PATENT OFFICE; Kyodo Bldg. 3-6, Nihonbashiningyocho 1-chome Chuo-ku, Tokyo 1030013 (JP)
Priority Data:
(JA) 遺伝子類導入方法
Abstract: front page image
(EN)An efficient method of transferring a gene to a target cell is provided. The method of transferring a gene to a target cell is characterized by adding or administering (A) a positively charged complex composed of the gene and a cationic substance and (B) a gas-containing small particle to a composition or living body containing the target cell and irradiating with a low-frequency ultrasonic wave.
(FR)L’invention concerne un procédé efficace de transfert d’un gène vers une cellule cible. Ce procédé de transfert d’un gène vers une cellule cible se caractérise par l’ajout ou l’administration (A) d’un complexe positivement chargé, composé du gène et d’une substance cationique, et (B) d’une petite particule contenant un gaz dans une composition ou un organisme vivant contenant la cellule cible, et par l’irradiation avec un ultrason basse fréquence.
(JA) 標的細胞への遺伝子の効率的な導入法を提供する。  標的細胞含有組成物又は生体に(A)遺伝子類とカチオン性物質とからなる正に荷電した複合体及び(B)ガス含有微小粒子を添加又は投与後、低周波超音波を照射することを特徴とする標的細胞への遺伝子類導入方法。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)