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1. WO2006126267 - GENE TRANSFER METHOD

Publication Number WO/2006/126267
Publication Date 30.11.2006
International Application No. PCT/JP2005/009637
International Filing Date 26.05.2005
IPC
C12N 15/87 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
A61K 48/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61N 7/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
7Ultrasound therapy
CPC
A61K 41/0028
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41Medicinal preparations obtained by treating materials with wave energy or particle radiation ; ; Therapies using these preparations
0028Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
A61K 47/42
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
42Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61K 48/0008
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
0008characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
A61K 9/0009
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
0009involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
A61K 9/127
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
Applicants
  • メビオファーム株式会社 MEBIOPHARM CO., LTD. [JP]/[JP] (AllExceptUS)
  • 丸山 一雄 MARUYAMA, Kazuo [JP]/[JP] (UsOnly)
  • 滝澤 知子 TAKIZAWA, Tomoko [JP]/[JP] (UsOnly)
  • 萩沢 康介 HAGISAWA, Kosuke [JP]/[JP] (UsOnly)
  • 西岡 利彦 NISHIOKA, Toshihiko [JP]/[JP] (UsOnly)
  • 柳衛 宏宣 YANAGIE, Hironobu [JP]/[JP] (UsOnly)
Inventors
  • 丸山 一雄 MARUYAMA, Kazuo
  • 滝澤 知子 TAKIZAWA, Tomoko
  • 萩沢 康介 HAGISAWA, Kosuke
  • 西岡 利彦 NISHIOKA, Toshihiko
  • 柳衛 宏宣 YANAGIE, Hironobu
Agents
  • 特許業務法人アルガ特許事務所 THE PATENT CORPORATE BODY ARUGA PATENT OFFICE
Priority Data
Publication Language Japanese (ja)
Filing Language Japanese (JA)
Designated States
Title
(EN) GENE TRANSFER METHOD
(FR) PROCEDE DE TRANSFERT DE GENE
(JA) 遺伝子類導入方法
Abstract
(EN) An efficient method of transferring a gene to a target cell is provided. The method of transferring a gene to a target cell is characterized by adding or administering (A) a positively charged complex composed of the gene and a cationic substance and (B) a gas-containing small particle to a composition or living body containing the target cell and irradiating with a low-frequency ultrasonic wave.
(FR) L’invention concerne un procédé efficace de transfert d’un gène vers une cellule cible. Ce procédé de transfert d’un gène vers une cellule cible se caractérise par l’ajout ou l’administration (A) d’un complexe positivement chargé, composé du gène et d’une substance cationique, et (B) d’une petite particule contenant un gaz dans une composition ou un organisme vivant contenant la cellule cible, et par l’irradiation avec un ultrason basse fréquence.
(JA)  標的細胞への遺伝子の効率的な導入法を提供する。  標的細胞含有組成物又は生体に(A)遺伝子類とカチオン性物質とからなる正に荷電した複合体及び(B)ガス含有微小粒子を添加又は投与後、低周波超音波を照射することを特徴とする標的細胞への遺伝子類導入方法。
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