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1. (WO2006126188) CXCR4 ANTAGONISTS FOR WOUND HEALING AND RE-EPITHELIALIZATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/126188    International Application No.:    PCT/IL2006/000596
Publication Date: 30.11.2006 International Filing Date: 21.05.2006
IPC:
A61K 38/10 (2006.01), A61K 38/00 (2006.01), A61K 38/02 (2006.01), A61K 38/16 (2006.01), C07K 2/00 (2006.01), C07K 14/00 (2006.01), C07K 7/08 (2006.01), C07K 7/04 (2006.01), C07K 1/00 (2006.01), C07K 1/107 (2006.01)
Applicants: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. [IL/IL]; P.O. Box 12000, 91120 Jerusalem (IL) (For All Designated States Except US).
KYOTO UNIVERSITY [JP/JP]; Shimoadachi-cho, Yoshida, Sakyo-ku, Kyoto 606-8501 (JP) (For All Designated States Except US).
PELED, Amnon [IL/IL]; (IL) (For US Only).
FUJII, Nobutaka [JP/JP]; (JP) (For US Only)
Inventors: PELED, Amnon; (IL).
FUJII, Nobutaka; (JP)
Agent: WEBB, Cynthia; Webb & Associates, P.O. Box 2189, 76121 Rehovot (IL)
Priority Data:
60/684,160 25.05.2005 US
Title (EN) CXCR4 ANTAGONISTS FOR WOUND HEALING AND RE-EPITHELIALIZATION
(FR) ANTAGONISTES DE CXCR4 POUR LA CICATRISATION DES BLESSURES ET LA REEPITHELIALISATION
Abstract: front page image
(EN)The present invention provides novel uses for CXCR4 antagonists, including specifically peptides of the T-140 family, in the treatment of skin burns and other injuries. The invention further provides methods for increasing epithelialization in a subject in need thereof, and for preventing or inhibiting fibrosis and excessive scar formation, using peptide inhibitors of the T-140 family as well as other CXCR4 antagonists.
(FR)La présente invention porte sur de nouvelles utilisations des antagonistes de CXCR4, comprenant spécifiquement des peptides de la famille T-140, dans le traitement des brûlures cutanées et autres lésions. L'invention porte également sur des méthodes visant à accroître l'épithélialisation chez un sujet, et à prévenir ou inhiber la fibrose et la formation excessive d'escarres en utilisant des inhibiteurs peptidiques de la famille T-140, ainsi que d'autres antagonistes de CXCR4.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)