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1. WO2006126040 - BACTERIAL AND BACTERIAL ASSOCIATED MIRNAS AND USES THEREOF

Publication Number WO/2006/126040
Publication Date 30.11.2006
International Application No. PCT/IB2005/002702
International Filing Date 25.05.2005
IPC
C12Q 1/68 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
CPC
C12Q 1/689
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6888for detection or identification of organisms
689for bacteria
C12Q 2600/158
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
158Expression markers
C12Q 2600/178
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
178miRNA, siRNA or ncRNA
Applicants
  • ROSETTA GENOMICS LTD. [IL]/[IL] (AllExceptUS)
  • BENTWICH, Itzhak [IL]/[IL] (UsOnly)
  • AVNIEL, Amir [IL]/[IL] (UsOnly)
Inventors
  • BENTWICH, Itzhak
  • AVNIEL, Amir
Priority Data
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) BACTERIAL AND BACTERIAL ASSOCIATED MIRNAS AND USES THEREOF
(FR) MIARN BACTERIENS ET DE TYPE BACTERIEN, ET UTILISATIONS CORRESPONDANTES
Abstract
(EN)
The present invention relates to a first group of novel bacterial and human associated oligonucleotides, here identified as 'Genomic Address Messenger' or 'GAM' oligonucleotide, and a second group of novel operon-like bacterial and human polynucleotides, here identified as 'Genomic Record' or 'GR' polynucleotide. GAM oligonucleotides selectively inhibit translation of known 'target' genes, many of which are known to be involved in various bacterial infections. Nucleic acid molecules are provided respectively encoding 21,916 bacterial and 6,100 human GAM precursor oligonucleotides, and 6,056 bacterial and 430 human GR polynucleotides, as are vectors and probes both comprising the nucleic acid molecules, and methods and systems for detecting GAM oligonucleotides and GR polynucleotides and specific functions and utilities thereof, for detecting expression of GAM oligonucleotides and GR polynucleotides, and for selectively enhancing and selectively inhibiting translation of the respective target genes thereof.
(FR)
L'invention se rapporte à un premier groupe de nouveaux oligonucléotides bactériens, associés aux êtres humains, appelés oligonucléotides 'messagers à adresse génomique' ou 'GAM', et à un deuxième groupe de nouveaux polynucléotides bactériens et humains, de type opéron, appelés polynucléotides 'd'enregistrement génomique' ou 'GR'. Les oligonucléotides GAM inhibent sélectivement la traduction de gènes cibles connus, dont plusieurs sont connus pour être impliqués dans diverses infections bactériennes. L'invention concerne également des molécules d'acide nucléique codant respectivement 21.916 oligonucléotides précurseurs GAM bactériens et 6.100 oligonucléotides précurseurs GAM humains, et 6.056 polynucléotides GR bactériens et 430 polynucléotides GR humains, ainsi que des vecteurs et des sondes comprenant respectivement les molécules d'acide nucléique. L'invention concerne en outre des procédés et des systèmes pour détecter des oligonucléotides GAM et des polynucléotides GR ainsi que leurs fonctions et utilités spécifiques, pour détecter l'expression des oligonucléotides GAM et des polynucléotides GR, et pour améliorer de manière sélective et inhiber de manière sélective la traduction des gènes cibles correspondants respectifs.
Also published as
EP5781248
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