WO2006125887 5H-PYRIDO[4,3-B]INDOLE DERIVATIVE COMPOUNDS AND USES THEREOF AS MEDICINE FOR TREATING POLYGLUTAMIN NEURODEGENERATIVE DISEASES

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Publication Number WO/2006/125887

Publication Date 30.11.2006

International Application No. PCT/FR2006/001107

International Filing Date 17.05.2006

IPC

CPC

Applicants

TROPHOS [FR]/[FR] (AllExceptUS)
PRUSS, Rebecca [FR]/[FR] (UsOnly)
JAMOT, Laure [FR]/[FR] (UsOnly)
DROUOT, Cyrille [FR]/[FR] (UsOnly)
SIMON, Céline [FR]/[FR] (UsOnly)

Inventors

PRUSS, Rebecca
JAMOT, Laure
DROUOT, Cyrille
SIMON, Céline

Agents

SANTARELLI

Priority Data

0505144

23.05.2005

Publication Language French (fr)

Filing Language French (FR)

Designated States

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Title

(EN) 5H-PYRIDO[4,3-B]INDOLE DERIVATIVE COMPOUNDS AND USES THEREOF AS MEDICINE FOR TREATING POLYGLUTAMIN NEURODEGENERATIVE DISEASES

(FR) COMPOSES DERIVES DE 5H-PYRIDO[4,3-B]INDOLE ET LEURS UTILISATIONS COMME MEDICAMENT POUR TRAITER LES MALADIES NEURODEGENERATIVES A POLYGLUTAMINES

Abstract

(EN) The invention concerns the treatment of neurodegenerative diseases. More particularly, it concerns a family of compounds derived from 5H-pyrido [4,3-b] indole for which a neuroprotecting activity has been shown. The invention concerns those novel products, their synthesis methods as well as certain likewise novel synthesis intermediates. The invention also concerns compositions comprising the compounds of said family, the use of said compounds as drugs, in particular for preparing a medicine for treating polyglutamin neurodegenerative diseases.

(FR) La présente invention se place dans le domaine du traitement des maladies neurodégénératives. Très particulièrement elle concerne une famille de composés dérivés de 5H-pyrido [4,3-b] indole pour lesquelles une activité neuroprotectrice a pu être démontrée. L’invention concerne ces produits nouveaux, leurs procédé de synthèse ainsi que certains intermédiaires de synthèse eux-mêmes nouveaux. La présente invention concerne également des compositions comprenant les composés de la famille, l'utilisation desdits composés à titre de médicaments, particulièrement dans la préparation d'un médicament destiné au traitement des maladies neurodégénératives à polyglutamines.

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
471	Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02	in which the condensed system contains two hetero rings
04	Ortho-condensed systems

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435	having six-membered rings with one nitrogen as the only ring hetero atom
4353	ortho- or peri-condensed with heterocyclic ring systems
437	the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25	Drugs for disorders of the nervous system
28	for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
471	Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02	in which the condensed system contains two hetero rings
04	Ortho-condensed systems

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435	having six-membered rings with one nitrogen as the only ring hetero atom
4353	ortho- or peri-condensed with heterocyclic ring systems
437	the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline

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1. WO2006125887 - 5H-PYRIDO[4,3-B]INDOLE DERIVATIVE COMPOUNDS AND USES THEREOF AS MEDICINE FOR TREATING POLYGLUTAMIN NEURODEGENERATIVE DISEASES