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1. WO2006125887 - 5H-PYRIDO[4,3-B]INDOLE DERIVATIVE COMPOUNDS AND USES THEREOF AS MEDICINE FOR TREATING POLYGLUTAMIN NEURODEGENERATIVE DISEASES

Publication Number WO/2006/125887
Publication Date 30.11.2006
International Application No. PCT/FR2006/001107
International Filing Date 17.05.2006
IPC
C07D 471/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/437 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
437the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A61P 25/28 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
CPC
C07D 471/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • TROPHOS [FR]/[FR] (AllExceptUS)
  • PRUSS, Rebecca [FR]/[FR] (UsOnly)
  • JAMOT, Laure [FR]/[FR] (UsOnly)
  • DROUOT, Cyrille [FR]/[FR] (UsOnly)
  • SIMON, Céline [FR]/[FR] (UsOnly)
Inventors
  • PRUSS, Rebecca
  • JAMOT, Laure
  • DROUOT, Cyrille
  • SIMON, Céline
Agents
  • SANTARELLI
Priority Data
050514423.05.2005FR
Publication Language French (fr)
Filing Language French (FR)
Designated States
Title
(EN) 5H-PYRIDO[4,3-B]INDOLE DERIVATIVE COMPOUNDS AND USES THEREOF AS MEDICINE FOR TREATING POLYGLUTAMIN NEURODEGENERATIVE DISEASES
(FR) COMPOSES DERIVES DE 5H-PYRIDO[4,3-B]INDOLE ET LEURS UTILISATIONS COMME MEDICAMENT POUR TRAITER LES MALADIES NEURODEGENERATIVES A POLYGLUTAMINES
Abstract
(EN) The invention concerns the treatment of neurodegenerative diseases. More particularly, it concerns a family of compounds derived from 5H-pyrido [4,3-b] indole for which a neuroprotecting activity has been shown. The invention concerns those novel products, their synthesis methods as well as certain likewise novel synthesis intermediates. The invention also concerns compositions comprising the compounds of said family, the use of said compounds as drugs, in particular for preparing a medicine for treating polyglutamin neurodegenerative diseases.
(FR) La présente invention se place dans le domaine du traitement des maladies neurodégénératives. Très particulièrement elle concerne une famille de composés dérivés de 5H-pyrido [4,3-b] indole pour lesquelles une activité neuroprotectrice a pu être démontrée. L’invention concerne ces produits nouveaux, leurs procédé de synthèse ainsi que certains intermédiaires de synthèse eux-mêmes nouveaux. La présente invention concerne également des compositions comprenant les composés de la famille, l'utilisation desdits composés à titre de médicaments, particulièrement dans la préparation d'un médicament destiné au traitement des maladies neurodégénératives à polyglutamines.
Related patent documents
EP6755493This application is not viewable in PATENTSCOPE because the national phase entry has not been published yet or the national entry is issued from a country that does not share data with WIPO or there is a formatting issue or an unavailability of the application.
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