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1. WO2006125784 - TRICYCLIC SPIRO DERIVATIVES AS CRTH2 MODULATORS

Publication Number WO/2006/125784
Publication Date 30.11.2006
International Application No. PCT/EP2006/062545
International Filing Date 23.05.2006
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
10
Spiro-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
407
condensed with heterocyclic ring systems, e.g. ketorolac, physostigmine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
08
Antiallergic agents
C07D 487/10 (2006.01)
A61K 31/407 (2006.01)
A61P 29/00 (2006.01)
A61P 37/08 (2006.01)
CPC
C07D 487/10
Applicants
  • LABORATOIRES SERONO S.A. [CH/CH]; Centre Industriel CH-1267 Coinsins, CH (AllExceptUS)
  • SCHWARZ, Matthias [CH/CH]; CH (UsOnly)
  • SEBILLE, Eric [FR/FR]; FR (UsOnly)
  • CLEVA, Christophe [FR/FR]; FR (UsOnly)
  • MERLOT, Cedric [FR/FR]; FR (UsOnly)
  • CHURCH, Dennis [US/CH]; CH (UsOnly)
  • PAGE, Patrick [FR/FR]; FR (UsOnly)
  • MACRITCHIE, Jacqueline A. [GB/GB]; GB (UsOnly)
  • ATHERALL, John Frederick [GB/GB]; GB (UsOnly)
  • CROSIGNANI, Stefano [IT/FR]; FR (UsOnly)
  • PUPOWICZ, Doris [DE/CH]; CH (UsOnly)
Inventors
  • SCHWARZ, Matthias; CH
  • SEBILLE, Eric; FR
  • CLEVA, Christophe; FR
  • MERLOT, Cedric; FR
  • CHURCH, Dennis; CH
  • PAGE, Patrick; FR
  • MACRITCHIE, Jacqueline A.; GB
  • ATHERALL, John Frederick; GB
  • CROSIGNANI, Stefano; FR
  • PUPOWICZ, Doris; CH
Agents
  • MERCK SERONO INTERNATIONAL S.A. INTELLECTUAL PROPERTY; 9, chemin des Mines CH-1202 Geneva, CH
Priority Data
05104428.724.05.2005EP
60/688,63108.06.2005US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TRICYCLIC SPIRO DERIVATIVES AS CRTH2 MODULATORS
(FR) DERIVES SPIRO TRICYCLIQUES SERVANT DE MODULATEURS DE CRTH2
Abstract
(EN)
The present invention is related to the use of spiro derivatives of Formula (I) for the treatment and/or prevention of allergic diseases, inflammatory dermatoses and other diseases with an inflammatory component. Specifically, the present invention is related to the use of spiro derivatives for the modulation of CRTH2 activity.
(FR)
L'invention concerne l'utilisation de dérivés spiro de formule (I) pour traiter et/ou pour prévenir des maladies allergiques, des dermatoses inflammatoires et d'autres maladies présentant une composante inflammatoire. En particulier, l'invention concerne l'utilisation de dérivés spiro pour moduler l'activité de CRTH2.
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