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1. WO2006125784 - TRICYCLIC SPIRO DERIVATIVES AS CRTH2 MODULATORS

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Publication Number WO/2006/125784
Publication Date 30.11.2006
International Application No. PCT/EP2006/062545
International Filing Date 23.05.2006
IPC
C07D 487/10 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
10Spiro-condensed systems
A61K 31/407 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
407condensed with heterocyclic ring systems, e.g. ketorolac, physostigmine
A61P 29/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A61P 37/08 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
08Antiallergic agents
CPC
A61K 31/427
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
425Thiazoles
427not condensed and containing further heterocyclic rings
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
A61P 17/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
A61P 17/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
04Antipruritics
A61P 19/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
Applicants
  • LABORATOIRES SERONO S.A. [CH]/[CH] (AllExceptUS)
  • SCHWARZ, Matthias [CH]/[CH] (UsOnly)
  • SEBILLE, Eric [FR]/[FR] (UsOnly)
  • CLEVA, Christophe [FR]/[FR] (UsOnly)
  • MERLOT, Cedric [FR]/[FR] (UsOnly)
  • CHURCH, Dennis [US]/[CH] (UsOnly)
  • PAGE, Patrick [FR]/[FR] (UsOnly)
  • MACRITCHIE, Jacqueline A. [GB]/[GB] (UsOnly)
  • ATHERALL, John Frederick [GB]/[GB] (UsOnly)
  • CROSIGNANI, Stefano [IT]/[FR] (UsOnly)
  • PUPOWICZ, Doris [DE]/[CH] (UsOnly)
Inventors
  • SCHWARZ, Matthias
  • SEBILLE, Eric
  • CLEVA, Christophe
  • MERLOT, Cedric
  • CHURCH, Dennis
  • PAGE, Patrick
  • MACRITCHIE, Jacqueline A.
  • ATHERALL, John Frederick
  • CROSIGNANI, Stefano
  • PUPOWICZ, Doris
Agents
  • MERCK SERONO INTERNATIONAL S.A. INTELLECTUAL PROPERTY
Priority Data
05104428.724.05.2005EP
60/688,63108.06.2005US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) TRICYCLIC SPIRO DERIVATIVES AS CRTH2 MODULATORS
(FR) DERIVES SPIRO TRICYCLIQUES SERVANT DE MODULATEURS DE CRTH2
front page image
Abstract
(EN) The present invention is related to the use of spiro derivatives of Formula (I) for the treatment and/or prevention of allergic diseases, inflammatory dermatoses and other diseases with an inflammatory component. Specifically, the present invention is related to the use of spiro derivatives for the modulation of CRTH2 activity.
(FR) L'invention concerne l'utilisation de dérivés spiro de formule (I) pour traiter et/ou pour prévenir des maladies allergiques, des dermatoses inflammatoires et d'autres maladies présentant une composante inflammatoire. En particulier, l'invention concerne l'utilisation de dérivés spiro pour moduler l'activité de CRTH2.
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