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Machine translation
1. (WO2006125632) AGONISTIC ANTIBODIES THAT BIND TO THE TWEAK RECEPTOR FN14 AND THEREBY MODULATE ADIPOSITY-ASSOCIATED PHENOTYPES AS WELL AS THEIR USE IN THERAPY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/125632    International Application No.:    PCT/EP2006/004974
Publication Date: 30.11.2006 International Filing Date: 24.05.2006
IPC:
A61K 39/395 (2006.01), C07K 14/705 (2006.01), C07K 16/28 (2006.01), A61K 39/00 (2006.01), A61P 3/04 (2006.01), G01N 33/50 (2006.01), A61K 48/00 (2006.01)
Applicants: RECHTSANWALT DR. MARTIN PRAGER ALS INSOLVENZVERWALTER ÜBER DAS VERMÖGEN DER XANTOS BIOMEDICINE AG, PLUTA RECHTSANWALTS GMBH [DE/DE]; Barthstrasse 16, 80339 München (DE) (For All Designated States Except US).
LINK, Dieter [DE/DE]; (DE) (For US Only)
Inventors: LINK, Dieter; (DE)
Agent: ZIMMER, Franz-Josef; Grünecker, Kinkeldey, Stockmair & Schwanhäusser, Maximilianstrasse 58, 80538 München (DE)
Priority Data:
05011275.4 24.05.2005 EP
60/689,914 13.06.2005 US
Title (EN) AGONISTIC ANTIBODIES THAT BIND TO THE TWEAK RECEPTOR FN14 AND THEREBY MODULATE ADIPOSITY-ASSOCIATED PHENOTYPES AS WELL AS THEIR USE IN THERAPY
(FR) ANTICORPS DE TYPE AGONISTES QUI SE LIENT AU RECEPTEUR TWEAK FN14 ET MODULENT PAR CONSEQUENT LES PHENOTYPES ASSOCIES A L'ADIPOSITE, ET LEUR UTILISATION A DES FINS THERAPEUTIQUES
Abstract: front page image
(EN)The present invention relates to agonists of the receptor Fn14 as well as their use for activating the signal pathway of the receptor Fn14 for interfering and/or modulating the differentiation of adipocytes and for use in adiposity/obesity and/or metabolic syndrome. In particular, the invention relates to agonists, preferably antibodies that inhibit the differentiation of pre-adipocytes to mature adipocytes and/or the storage of lipid molecules in differentiating or mature adipocytes by receptor-mediated signal transduction.
(FR)L'invention concerne des agonistes du récepteur Fn14, ainsi que leur utilisation pour activer la voie de signalisation du récepteur Fn14, pour perturber et/ou moduler la différenciation des adipocytes, et pour prévenir et/ou traiter une adiposité/obésité et/ou un syndrome métabolique. Cette invention concerne en particulier des agonistes, de préférence des anticorps qui inhibent la différenciation de pré-adipocytes vers des adipocytes mûrs, et/ou le stockage de molécules lipidiques chez des adipocytes en cours de différenciation ou des adipocytes mûrs, par une transduction de signaux dont la médiation est assurée par ledit récepteur.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)