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1. (WO2006125227) FIBROBLAST ACTIVATION PROTEIN INHIBITOR COMPOUNDS AND METHODS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/125227    International Application No.:    PCT/US2006/019876
Publication Date: 23.11.2006 International Filing Date: 18.05.2006
IPC:
C07F 5/02 (2006.01), A61K 31/00 (2006.01), A61P 35/00 (2006.01)
Applicants: GENENTECH, INC. [US/US]; MS 49, 1 Dna Way, South San Francisco, California 94080 (US) (For All Designated States Except US).
COHEN, Frederick [US/US]; (US) (For US Only).
FAIRBROTHER, Wayne J. [NZ/US]; (US) (For US Only).
QUAN, Clifford [US/US]; (US) (For US Only).
SUTHERLIN, Daniel P. [US/US]; (US) (For US Only).
WOLF, Beni B. [US/US]; (US) (For US Only)
Inventors: COHEN, Frederick; (US).
FAIRBROTHER, Wayne J.; (US).
QUAN, Clifford; (US).
SUTHERLIN, Daniel P.; (US).
WOLF, Beni B.; (US)
Agent: ANDRUS, Alex; c/o GENENTECH, INC., 1 Dna Way, Ms 49, South San Francisco, California 94080 (US)
Priority Data:
60/682,970 19.05.2005 US
60/730,292 25.10.2005 US
Title (EN) FIBROBLAST ACTIVATION PROTEIN INHIBITOR COMPOUNDS AND METHODS
(FR) COMPOSES INHIBITEURS DE PROTEINES D'ACTIVATION DE FIBROBLASTES ET PROCEDES
Abstract: front page image
(EN)Amino terminus-blocked peptide boronate compounds of Formulas (I) and (II) are useful for inhibiting Fibroblast Activation Protein (FAP) and other proteases, and for treating disorders mediated by FAP. Methods of using the amino terminus blocked peptide boronate compounds, and stereoisomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
(FR)La présente invention a trait à des composés de boronate de peptide à blocage de terminaison amino de formules (I) et (II) utiles pour l'inhibition de la protéine d'activation de fibroblastes et d'autres protéases, et pour le traitement de troubles médiés par la protéine d'activation de fibroblastes. L'invention a également trait à des procédés d'utilisation des composés de boronate de peptide à blocage de terminaison amino, et de stéréoisomères, tautomères, solvates et de sels pharmaceutiquement acceptables de ceux-ci, pour le diagnostic, in vitro, in situ, et in vivo, la prévention ou le traitement de tels troubles dans des cellules mammaliennes, ou de conditions pathologiques associées.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)