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1. (WO2006124904) CANCER TREATMENT BY COMBINED INHIBITION OF TELOMERASE AND HSP90 ACTIVITIES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/124904    International Application No.:    PCT/US2006/018927
Publication Date: 23.11.2006 International Filing Date: 16.05.2006
Chapter 2 Demand Filed:    16.03.2007    
IPC:
C12Q 1/68 (2006.01), A01N 43/04 (2006.01), C07H 21/04 (2006.01), A61K 31/07 (2006.01)
Applicants: GERON CORPORATION [US/US]; 230 Constitution Drive, Menlo Park, CA 94025 (US) (For All Designated States Except US).
DANA-FARBER CANCER INSTITUTE [US/US]; 44 BINNEY STREET, Longwood Bldg. (l) Room 215, Boston, MA 02115 (US) (For All Designated States Except US).
MUNSHI, Nikhil, C. [US/US]; (US) (For US Only).
SHAMMAS, Masood, A. [PK/US]; (US) (For US Only).
GRYAZNOV, Sergei [US/US]; (US) (For US Only)
Inventors: MUNSHI, Nikhil, C.; (US).
SHAMMAS, Masood, A.; (US).
GRYAZNOV, Sergei; (US)
Agent: DEHLINGER, Peter, J.; PERKINS COIE LLP, P.o. Box 2168, Menlo Park, CA 94026 (US)
Priority Data:
60/682,029 16.05.2005 US
Title (EN) CANCER TREATMENT BY COMBINED INHIBITION OF TELOMERASE AND HSP90 ACTIVITIES
(FR) TRAITEMENT DU CANCER PAR INHIBITION COMBINEE DE TELOMERASE ET D'ACTIVITES HSP90
Abstract: front page image
(EN)A method and kit for inhibiting the proliferation of cancer cells are disclosed, based on a combination of an HSP90 inhibitor and a telomerase inhibitor. When used in cancer therapy, the two compounds in combination enhance the anti-cancer treatment efficacy obtained with the HSP90 inhibitor alone or the telomerase inhibitor alone. Preferably, efficacy is supraadditive or synergistic in nature relative to the combined effects of the individual agents, with minimal exacerbation of side effects.
(FR)L'invention concerne un procédé et un nécessaire destinés à inhiber la prolifération de cellules cancéreuses, sur la base d'une combinaison d'un inhibiteur de HSP90 et d'un inhibiteur de télomerase. Lorsqu'ils sont utilisés en thérapie contre le cancer, ces deux composés combinés améliorent l'efficacité du traitement contre le cancer obtenu à l'aide d'un inhibiteur de HSP90 seul ou d'un inhibiteur de télomerase seul. De préférence, l'efficacité est de nature supra-additive ou synergique par rapport aux effets combinés d'agents individuels, avec une exacerbation minimale des effets secondaires.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)