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1. WO2006124875 - DIARYLSULFONE SULFONAMIDES AND USE THEROF

Publication Number WO/2006/124875
Publication Date 23.11.2006
International Application No. PCT/US2006/018886
International Filing Date 12.05.2006
IPC
C07C 317/20 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
317Sulfones; Sulfoxides
16having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
20with sulfone or sulfoxide groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
C07C 317/22 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
317Sulfones; Sulfoxides
16having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
22with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
C07C 317/26 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
317Sulfones; Sulfoxides
26having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
C07C 317/38 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
317Sulfones; Sulfoxides
26having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
32with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
34having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
38with the nitrogen atom of at least one amino group being part of any of the groups X being a hetero atom, Y being any atom, e.g. N-acylaminosulfones
A61K 31/445 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
445Non-condensed piperidines, e.g. piperocaine
CPC
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 19/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
A61P 19/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
08for bone diseases, e.g. rachitism, Paget's disease
A61P 19/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
08for bone diseases, e.g. rachitism, Paget's disease
10for osteoporosis
A61P 21/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
21Drugs for disorders of the muscular or neuromuscular system
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • WYETH [US]/[US] (AllExceptUS)
  • GOPALSAMY, Ariamala (UsOnly)
  • MOORE, William, Jay [US]/[US] (UsOnly)
  • KERN, Jeffery, Curtis [US]/[US] (UsOnly)
  • MOLINARI, Albert, John [US]/[US] (UsOnly)
  • SHI, Mengxiao [CN]/[US] (UsOnly)
  • WELMAKER, Gregory, Scott [US]/[US] (UsOnly)
  • WILSON, Matthew, Allan [US]/[US] (UsOnly)
  • KRISHNAMURTHY, Girija [US]/[US] (UsOnly)
  • COMMONS, Thomas, Joseph [US]/[US] (UsOnly)
  • WEBB, Michael, Byron [US]/[US] (UsOnly)
  • WOODWORTH, Richard, P. [US]/[US] (UsOnly)
Inventors
  • GOPALSAMY, Ariamala
  • MOORE, William, Jay
  • KERN, Jeffery, Curtis
  • MOLINARI, Albert, John
  • SHI, Mengxiao
  • WELMAKER, Gregory, Scott
  • WILSON, Matthew, Allan
  • KRISHNAMURTHY, Girija
  • COMMONS, Thomas, Joseph
  • WEBB, Michael, Byron
  • WOODWORTH, Richard, P.
Agents
  • LUCCI, Joseph
Priority Data
11/432,78810.05.2006US
60/681,08013.05.2005US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) DIARYLSULFONE SULFONAMIDES AND USE THEROF
(FR) SULFAMIDES DE DIARYLSULFONE ET LEUR UTILISATION
Abstract
(EN) Compounds of Formula (I), or pharmaceutically acceptable salts thereof, are provided, which are modulators of secreted frizzled related protein-1. The compounds, and compositions containing the compounds, can be used to treat a variety of disorders, including osteoporosis.
(FR) L'invention porte sur des composés de formule (I), ou sur leurs sels acceptables d'un point de vue pharmaceutique, qui sont des modulateurs de la protéine Frizzled sécrétée 1. Les composés et les compositions contenant ces composés peuvent être utilisés pour traiter diverses pathologiques telles que l'ostéoporose.
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