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1. (WO2006124807) TRANSDERMAL METHOD AND PATCH FOR NAUSEA

Pub. No.:    WO/2006/124807    International Application No.:    PCT/US2006/018786
Publication Date: Nov 23, 2006 International Filing Date: May 16, 2006
IPC: A61F 13/00
Applicants: ABEILLE PHARMACEUTICALS, INC.
PATEL, Kalpana
BORSADIA, Suresh
Inventors: PATEL, Kalpana
BORSADIA, Suresh
Title: TRANSDERMAL METHOD AND PATCH FOR NAUSEA
Abstract:
Provided, among other things, is a method of treating acute, delayed or anticipatory emesis for a sustained period in an individual, which involves applying to a portion of intact skin on the individual a composition of i. an antiemetically effective amount of a 5-HT3 receptor antagonist; ii. a permeation enhancing amount of permeation enhancer comprising 0.5% to 15% by weight of the skin-contacting layer; and iii. an adhesive, wherein a plasma concentration of the 5-HT3 receptor antagonist in a therapeutically effective range is provided for period of time from an onset time to 12 hours or more after the composition is removed.