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1. (WO2006124661) PROGNOSIS AND TREATMENT OF BREAST CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/124661    International Application No.:    PCT/US2006/018527
Publication Date: 23.11.2006 International Filing Date: 12.05.2006
IPC:
A61K 39/395 (2006.01), A61K 38/00 (2006.01)
Applicants: TRUSTEES OF DARTMOUTH COLLEGE [US/US]; Technology Transfer Office, 11 Rope Ferry Road, Hanover, NH 03755-1404 (US) (For All Designated States Except US).
KINLAW, William, B., III [US/US]; (US) (For US Only)
Inventors: KINLAW, William, B., III; (US)
Agent: LICATA, Jane, Massey; LICATA & TYRRELL P.C., 66 E. Main Street, Marlton, NJ 08053 (US)
Priority Data:
60/681,683 17.05.2005 US
60/737,223 16.11.2005 US
Title (EN) PROGNOSIS AND TREATMENT OF BREAST CANCER
(FR) PRONOSTIC ET TRAITEMENT DE CANCER DU SEIN
Abstract: front page image
(EN)The present invention relates to an antibody which specifically binds a Spot 14 (S14 or THRSP) protein in human breast cancer cells and a method for using the same to predict disease -free survival and select treatment modalities for breast cancer. The present invention is also a method for inducing apoptosis in breast cancer cells by inhibiting the expression or activity of Spot 14. Compositions and methods for treating breast cancer are also provided.
(FR)L'invention concerne un anticorps qui lie spécifiquement une protéine Spot 14 (S14 ou THRSP) dans des cellules cancéreuses présentes dans un sein humain et un procédé d'utilisation dudit anticorps pour prédire un taux de survie sans récidive et pour sélectionner des modalités de traitement du cancer du sein. Cette invention concerne également une méthode d'induction de l'apoptose dans des cellules cancéreuses du sein par inhibition de l'expression ou de l'activité de Spot 14. L'invention concerne également des compositions et des méthodes de traitement du cancer du sein.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)