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1. (WO2006124494) TRANSITION-STATE INHIBITORS OF PIN1, &agr;-KETOAMIDE-CONTAINING PEPTIDOMIMETICS, AND SYNTHESES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/124494    International Application No.:    PCT/US2006/018196
Publication Date: 23.11.2006 International Filing Date: 12.05.2006
IPC:
A61K 38/16 (2006.01), A61K 31/401 (2006.01), C07D 207/12 (2006.01)
Applicants: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. [US/US]; 2200 Kraft Drive, Suite 1050, Blacksburg, VA 24060 (US) (For All Designated States Except US).
ETZKORN, Felicia [US/US]; (US) (For US Only)
Inventors: ETZKORN, Felicia; (US)
Agent: WHITHAM, Michael, E.; Whitman, Curtis, Christofferson & Cook, P.C., 11491 Sunset Hills Road, Suite 340, Reston, VA 20190 (US)
Priority Data:
60/680,518 13.05.2005 US
11/383,085 12.05.2006 US (IA Considered Withdrawn 24.08.2006)
Title (EN) TRANSITION-STATE INHIBITORS OF PIN1, &agr;-KETOAMIDE-CONTAINING PEPTIDOMIMETICS, AND SYNTHESES THEREOF
(FR) INHIBITEURS D'ETAT DE TRANSITION DE PIN1, CONSTITUES PAR DES COMPOSES PEPTIDOMIMETIQUES CONTENANT UN $G(A)-CETOAMIDE, ET SYNTHESE DE CEUX-CI
Abstract: front page image
(EN)Novel &agr;-ketoamide-containing peptidomimetics are provided, such as peptidomimetics containing an &agr;-ketoamide Ser-Pro dipeptide analogue. The &agr;- ketoamide is preferably incorporated into another molecule as a Pinl inhibitor (such as a pentapeptide analogue Ac-Phe-Tyr-pSer-Pro-Arg-NH2).
(FR)Cette invention concerne de nouveaux composés peptidomimétiques contenant un a-cétoamide, tels que des composés peptidomimétiques contenant un analogue de dipeptide Ser-Pro de a-cétoamide. Le a- cétoamide est de préférence incorporé dans une autre molécule comme inhibiteur de Pin1 (telle qu'un analogue pentapeptide Ac-Phe-Tyr-pSer-Pro-Arg-NH2).
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)